Adults 18 to 75, any sex, with Spinal Cord Injury. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change From Baseline of Lower Extremity Independence Time During 10 Min Standing Bout After 160 Sessions (1 Year)Primary· Baseline, 160 sessions (1 year)
We will measure the amount of time individuals are able to stand without manual assistance (independently) throughout a 10 min bout
Group
Value
95% CI
Epidural Stimulator
40.6
± 30.2
Change From Baseline of Stepping Independence Time During 6 Min Stepping Bout After 160 Sessions (1 Year)Primary· Baseline, 160 session (1 year)
We will measure the number of steps individuals are able to take without manual assistance (independently) throughout a 6 min stepping bout
Group
Value
95% CI
Epidural Stimulator
197.13
± 421.89
Change From Baseline of Number of Consecutive Hip Flexion Repetitions Performed Within One Minute After 160 Sessions (1 Year)Secondary· Baseline, 160 sessions (1 year)
We will measure the ability of the individuals to perform consecutive hip flexion repetitions with stimulation during a 1 minute period
Group
Value
95% CI
Epidural Stimulator
14.25
± 9.8
Adverse events — posted to ClinicalTrials.gov
Time frame: From implant through the end of the second intervention, an average of one year..
Reporting threshold: 5%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
The overall aim is to assess whether task specific locomotor training and spinal cord electrical stimulation (SCES) can induce neural reorganization of the functionally isolated human spinal cord to improve standing and stepping in individuals with functionally complete SCI. The investigators propose that locomotor training will result in generation of more effective standing and stepping efferent patterns by restoring phase dependent modulation of reflexes and reciprocal inhibition, reducing clonus and mediating interlimb coordination. The investigators propose that the SCES will optimize the physiological state of the spinal cord interneuronal circuitry compromised by compensating for loss of supraspinal input for the retraining of these tasks.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
NCT05926596 — Leg Stretching Using an Exoskeleton on Demand for People With Spasticity
· NA
· recruiting
NCT06839300 — The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
· recruiting
NCT07036107 — A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the S
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Louisville
Last refreshed: 22 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02339233.