NCT02335021 (AFS-adult) is a NA clinical trial of Sucralose in Impairment of Oral Perception, sponsored by Yale University.

Who is sponsoring NCT02335021?

NCT02335021 is sponsored by Yale University.

What drugs are being tested in NCT02335021?

Interventions in NCT02335021: Sucralose, Sucrose, Sucralose + maltodextrin, Sucralose + Sucrose.

What condition does NCT02335021 study?

NCT02335021 studies Impairment of Oral Perception, Insulin Resistance.

Is NCT02335021 still recruiting?

NCT02335021 is currently completed. Last updated 26 September 2019.

Last reviewed 2019-09-26 · How we verify

NCT02335021: AFS-adult

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults

Completed NA Last updated 26 September 2019

What this trial tests

NA trial testing Sucralose in Impairment of Oral Perception in 97 participants. Completed in 24 April 2019.

Timeline

1 January 2015

Primary endpoint
24 April 2019

24 April 2019

Quick facts

Lead sponsor	Yale University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	97
Start date	1 January 2015
Primary completion	24 April 2019
Estimated completion	24 April 2019
Sites	1 location across United States

Drugs / interventions tested

Sucralose — full drug profile →
Sucrose — full drug profile →
Sucralose + maltodextrin
Sucralose + Sucrose

Conditions studied

Impairment of Oral Perception — all drugs for Impairment of Oral Perception →
Insulin Resistance — all drugs for Insulin Resistance →

Sponsor

Yale University

Who can join

Adults 23 to 45, any sex, with Impairment of Oral Perception or Insulin Resistance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults. The investigators hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce brain response in amygdala to sweet taste compared to sucrose.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, et al · · 2020 · cited 112× · PMID 32130881 · DOI 10.1016/j.cmet.2020.01.014

Verify or expand the search:

Other trials of Sucralose

Trials testing the same drug.

NCT07124585 — Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes · NA · not yet recruiting
NCT07377097 — Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects · NA · not yet recruiting
NCT07231133 — Effect of Within-Meal Consumption of Allulose on Diet-induced Thermogenesis · NA · completed
NCT05575687 — Brain and Glycemic Responses to Sweet Soft Drinks · NA · completed
NCT05279183 — Assessment of Reward Responses to Erythritol Using Flavor Preference Learning · NA · completed

Other Yale University trials

Trials by the same sponsor.

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NCT07398404 — A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Pa · Phase 1, PHASE2 · not yet recruiting
NCT07305324 — Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02335021 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yale University
Last refreshed: 26 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02335021.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing