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NCT02315859
Validation of New Non-Invasive Parameters of Diastolic Suction in the Left Ventricle
trial in Diastolic Heart Failure in 40 participants. Completed in 30 June 2017.
31 December 2016
Quick facts
| Lead sponsor | Insel Gruppe AG, University Hospital Bern |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 31 December 2014 |
| Primary completion | 31 December 2016 |
| Estimated completion | 30 June 2017 |
| Sites | 1 location across Switzerland |
Conditions studied
- Diastolic Heart Failure — all drugs for Diastolic Heart Failure →
Sponsor
Insel Gruppe AG, University Hospital Bern
Who can join
18 and older, any sex, with Diastolic Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It is known that, at the end of the cardiac ejection period, potential energy is stored in elastic fibers of the heart, which promotes the suction of blood from the atria during early filling. The investigators have developed a new ultrasound-based method to quantify this suction effect. Here, it is necessary to reduce the complex 3-dimensional cardiac mechanics in a 1-dimensional (piston-like) pump system. In the study, several steps of model reduction will be tested. Each reduction is intended to allow non-invasive measurements to become increasingly simple and feasible at reduced echo quality. The reference method is the invasive data obtained from a pressure-volume conductance catheter. To increase the supply of potential energy in the elastic fibers, a substance (dobutamine) is administered for transient strengthening of the force of contraction. Hypothesis: There is a good agreement between the new, non-invasive parameters and the invasive reference method for the quantification of the suction effect of the left ventricle, and the good correlation persists even with increasing model simplification.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT02315859
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Related trials
Other recruiting trials for Diastolic Heart Failure
Currently open trials in the same condition.
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- NCT05064709 — Assessment of CCM in HF With Higher Ejection Fraction · NA · recruiting
- NCT04160000 — Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure · Phase 4 · recruiting
Other Insel Gruppe AG, University Hospital Bern trials
Trials by the same sponsor.
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- NCT07478536 — Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial) · not yet recruiting
- NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02315859 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Insel Gruppe AG, University Hospital Bern
- Last refreshed: 28 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02315859.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing