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NCT02307890
The Relationship of Initial Liver Profile and Outcome After Transplantation
trial in Liver Failure in 100 participants. Completed in 1 December 2018.
1 December 2018
Quick facts
| Lead sponsor | University of Edinburgh |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 6 August 2014 |
| Primary completion | 1 December 2018 |
| Estimated completion | 1 December 2018 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Liver Failure — all drugs for Liver Failure →
Sponsor
University of Edinburgh
Who can join
16 and older, any sex, with Liver Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Donation after cardiac death (DCD) livers are increasingly utilised in liver transplantation but concerns exist regarding negative results. Ischemic cholangiopathy (IC) is damage to one or more bile ducts probably caused by inadequate blood flow or a failure of biliary epithelium to regenerate. It typically presents weeks to months after liver transplantation, is often refractory to treatment and can result in a requirement for re-transplantation. Although IC is more common following DCD liver transplantation, it is otherwise very difficult to predict and the underlying pathogenesis is poorly understood. The aim of this study is to correlate microRNA (miRNA) levels and markers of senescence in liver and bile duct biopsies taken during liver transplantation with the incidence of IC following liver transplantation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Nucleic acid biomarkers to assess graft injury after liver transplantation.
Bardhi E, McDaniels J, Rousselle T, Maluf DG, et al · · 2022 · cited 15× · PMID 35243279 · DOI 10.1016/j.jhepr.2022.100439
Verify or expand the search:
- PubMed search for NCT02307890
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other University of Edinburgh trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02307890 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02307890.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing