NCT02281747

Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries

Active, enrolled Last updated 16 January 2026

What this trial tests

trial in Rheumatoid Arthritis in 521,292 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

24 October 2014

Primary endpoint
30 May 2029

31 May 2029

Quick facts

Lead sponsor	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	521,292
Start date	24 October 2014
Primary completion	30 May 2029
Estimated completion	31 May 2029
Sites	1 location across United States

Conditions studied

• Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
• Ankylosing Spondylitis — all drugs for Ankylosing Spondylitis →

Sponsor

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Who can join

Adults 20 to 100, any sex, with Rheumatoid Arthritis or Ankylosing Spondylitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- Orthopedic procedures are common in the United States. These include joint replacement and spine surgeries. Researchers want to study data about these procedures over time. They want to see if treatment has gotten better. They also want to find ways to change the care that people get before and after they have these procedures. These changes may lower the risk of problems people can have during and after treatment. They may also improve people s results.

Objectives:

\- To study a series of questions about surgery, medicine, treatments, and outcomes for orthopedic procedures.

Eligibility:

\- Data from the U.S. Centers for Medicare and Medicaid Services from 1999 to 2015.

Design:

* Researchers will look at data for people ages 20-100.
* No new participants will be used in this study.
* The study will last 6 years.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.