NCT02281331

Optimal Exercise Training and Nutrition Supplementation in Older Men

Completed NA Last updated 16 August 2018

What this trial tests

NA trial testing Supplement in Aging in 50 participants. Completed in 1 May 2018.

Timeline

1 October 2014

Primary endpoint
1 December 2016

1 May 2018

Quick facts

Lead sponsor	McMaster University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	50
Start date	1 October 2014
Primary completion	1 December 2016
Estimated completion	1 May 2018
Sites	1 location across Canada

Drugs / interventions tested

• Supplement

Conditions studied

• Aging — all drugs for Aging →

Sponsor

McMaster University

Who can join

60 and older, male only, with Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial.
   Bell KE, Snijders T, Zulyniak M, Kumbhare D, et al · · 2017 · cited 82× · PMID 28719669 · DOI 10.1371/journal.pone.0181387
2. Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway.
   Allison DJ, Nederveen JP, Snijders T, Bell KE, et al · · 2019 · cited 45× · PMID 30649918 · DOI 10.1152/ajpcell.00448.2018
3. A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases <i>N</i>-3 Index in Healthy Older Men: A Randomized Controlled Trial.
   Bell KE, Fang H, Snijders T, Allison DJ, et al · · 2019 · cited 19× · PMID 31143111 · DOI 10.3389/fnagi.2019.00107
4. Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men.
   Bell KE, Brook MS, Snijders T, Kumbhare D, et al · · 2019 · cited 14× · PMID 31032258 · DOI 10.3389/fnut.2019.00040
5. Ingestion of a Multi-Ingredient Supplement Does Not Alter Exercise-Induced Satellite Cell Responses in Older Men.
   Snijders T, Bell KE, Nederveen JP, Saddler NI, et al · · 2018 · cited 11× · PMID 29878269 · DOI 10.1093/jn/nxy063