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Repetitive Exposure of Intermittent Hypoxia to Enhance Walking Recovery in Persons With Chronic Spinal Cord Injury
The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time. The investigators hypothesize: * Acute intermittent hypoxia (AIH) exposure will increase maximum voluntary leg strength in persons with incomplete cervical spinal cord injury (SCI) * AIH exposure will increase multijoint reflex excitability of leg muscles in persons with incomplete cervical SCI * AIH exposure will increase walking performance in persons with incomplete cervical SCI
Details
| Lead sponsor | Spaulding Rehabilitation Hospital |
|---|---|
| Phase | NA |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 30 |
| Start date | 2014-10 |
| Completion | 2027-11 |
Conditions
- Spinal Cord Injuries
Interventions
- SHAM - Intermittent Room Air - room air mixture
- AIH - Intermittent Hypoxia - hypoxia air mixture
Primary outcomes
- Change in overground walking endurance — Baseline, immediately following intervention (day 5), and at 1, 2, and 4 weeks
walking endurance (6 minute walk test - how far one can walk in 6 minutes)
Countries
United States