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NCT02271932
Multi-institutional Trial of Non-operative Management of Appendicitis
trial testing Non-operative in Appendicitis in 1,076 participants. Status unknown.
1 November 2019
Quick facts
| Lead sponsor | Nationwide Children's Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 1,076 |
| Start date | 1 October 2014 |
| Primary completion | 1 November 2019 |
| Estimated completion | 1 November 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Non-operative
Conditions studied
- Appendicitis — all drugs for Appendicitis →
Sponsor
Nationwide Children's Hospital
Who can join
Adults 8 to 17, male only, with Appendicitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A successful non-operative management strategy for early appendicitis will decrease the number of children requiring surgery and may improve the quality of care related to the treatment of appendicitis. To account for the child-family perspective and treatment preferences, the investigators will perform a study in which patients and their families choose between antibiotics alone (Non-operative group) or appendectomy (Surgery group) at ten U.S. hospitals. This study will determine the effectiveness of non-operative management of early appendicitis with antibiotics alone in children and compare differences in morbidity, disability, quality of life, satisfaction, and cost between families choosing surgery or non-operative management.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis.
Minneci PC, Hade EM, Lawrence AE, Sebastião YV, et al · · 2020 · cited 100× · PMID 32730561 · DOI 10.1001/jama.2020.10888 -
Demographic and Clinical Characteristics Associated With the Failure of Nonoperative Management of Uncomplicated Appendicitis in Children: Secondary Analysis of a Nonrandomized Clinical Trial.
Minneci PC, Hade EM, Gil LA, Metzger GA, et al · · 2022 · cited 7× · PMID 35499827 · DOI 10.1001/jamanetworkopen.2022.9712
Verify or expand the search:
- PubMed search for NCT02271932
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Non-operative
Trials testing the same drug.
- NCT06444828 — Comparing Outcomes of Non-surgical Versus Surgical Treatment of Shoulder Fractures With Different Shoulder Replacements · NA · active not recruiting
Other recruiting trials for Appendicitis
Currently open trials in the same condition.
- NCT07115303 — Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure · NA · recruiting
- NCT06395636 — Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients · NA · recruiting
- NCT07049965 — Comparative Study of Harmonic Scalpel vs. Suture Ligation for Appendix Base During Laparoscopic Appendectomy · NA · active not recruiting
- NCT07478029 — Clinical Study of PEG Bowel Preparation in Appendectomy Patients · recruiting
- NCT06177418 — Transumbilical Laparoscopic Appendectomy · NA · recruiting
Other Nationwide Children's Hospital trials
Trials by the same sponsor.
- NCT07035912 — Novel PIONEER© Protocol: RCT · NA · not yet recruiting
- NCT07435792 — TetraGraph to Evaluate Onset and Recovery Times of Rocuronium · NA · not yet recruiting
- NCT07026942 — Phase I/II Clinical Trial of Universal Donor CD33 CAR Natural Killer Cells for AML · Phase 1, PHASE2 · not yet recruiting
- NCT06795126 — Little NIRVANA for Pediatric Pain and Anxiety · NA · enrolling by invitation
- NCT06854991 — Healthy Children and Virtual Reality Mediation of Simulated Pain · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02271932 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nationwide Children's Hospital
- Last refreshed: 9 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02271932.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing