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Taste Physiology in Healthy, Normal-weight Volunteers
Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.
Details
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 12 |
| Start date | 2013-03 |
| Completion | 2013-10 |
Conditions
- Exploratory Behavior
Interventions
- Single intragastric instillation of 200 mL tap water via nasogastric tube
- Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube
- Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube
- Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube
- Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube
- Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube
Primary outcomes
- regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI) — changes from baseline to one hour after treatment
Changes in resting state functional connectivity
Countries
Switzerland