Acute Cardioversion Versus Wait And See-approach for Symptomatic Atrial Fibrillation in the Emergency Department (RACE 7 ACWAS-trial)

NCT02248753 NA COMPLETED

A symptomatic episode of the heart rhythm disorder 'atrial fibrillation' (AF) is a frequent reason for visits to the emergency department. Currently, in the majority of cases, immediate (electrical or pharmacological) cardioversion is chosen, while atrial fibrillation terminates spontaneously in 70% of the cases within 24 hours. A wait-and-see approach with rate-control medication only, and when needed cardioversion within 48 hours of onset of symptoms, could be effective, safe and more cost-effective than current standard of care and could lead to a higher quality of life.

Details

Lead sponsor	Maastricht University Medical Center
Phase	NA
Status	COMPLETED
Enrolment	437
Start date	2014-10
Completion	2019-12

Conditions

• Atrial Fibrillation

Interventions

• Pharmacological cardioversion - Flecainide
• Electrical cardioversion
• Metoprolol
• Verapamil
• Digoxin
• Pharmacological cardioversion - Amiodarone

Primary outcomes

• 12-lead ECG — 4 weeks
  Presence of sinus rhythm on ECG

Countries

Netherlands