NCT02235974: CPASS

Critical Periods After Stroke Study (CPASS)

Status unknown NA Last updated 7 April 2020

What this trial tests

NA trial testing Early Intensive upper extremity motor training in Stroke in 150 participants. Status unknown.

Timeline

26 August 2014

Primary endpoint
31 December 2020

31 January 2021

Quick facts

Lead sponsor	MedStar National Rehabilitation Network
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	150
Start date	26 August 2014
Primary completion	31 December 2020
Estimated completion	31 January 2021
Sites	1 location across United States

Drugs / interventions tested

• Early Intensive upper extremity motor training
• Sub-acute intensive upper extremity motor training
• Chronic intensive upper extremity motor training
• Control

Conditions studied

• Stroke — all drugs for Stroke →
• Brain Infarction — all drugs for Brain Infarction →
• Brain Ischemia — all drugs for Brain Ischemia →
• Cerebral Infarction — all drugs for Cerebral Infarction →

Sponsor

MedStar National Rehabilitation Network

Who can join

21 and older, any sex, with Stroke or Brain Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To perform an exploratory single center randomized study that will form the basis for a larger scale, more definitive randomized clinical trial to determine the optimal time after stroke for intensive motor training. The investigators will perform a prospective exploratory study of upper extremity (UE) motor training delivered at higher than usual intensity at three different time points after stroke:

* early (initiated within 30 days)
* subacute/outpatient (initiated within 2-3 months)
* chronic (initiated within 6-9 months)

The control group will not receive the therapy intervention during the 1-year study.

Outcome measures will be assessed at baseline, pre-treatment, post-treatment, 6 months and one year after stroke onset.

Compared to individuals randomized during the outpatient (2-3 months after stroke onset) or chronic (6-9 months after stroke onset) time points, participants randomized to early intensive motor training will show greater upper extremity motor improvement measured at one year post stroke.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Repetitive task training for improving functional ability after stroke.
   French B, Thomas LH, Coupe J, McMahon NE, et al · · 2016 · cited 231× · PMID 27841442 · DOI 10.1002/14651858.cd006073.pub3
2. Why Are Stroke Rehabilitation Trial Recruitment Rates in Single Digits?
   Geed S, Feit P, Edwards DF, Dromerick AW. · · 2021 · cited 15× · PMID 34168611 · DOI 10.3389/fneur.2021.674237
3. The Critical Period After Stroke Study (CPASS) Upper Extremity Treatment Protocol.
   Barth J, Geed S, Mitchell A, Brady KP, et al · · 2023 · cited 4× · PMID 37744191 · DOI 10.1016/j.arrct.2023.100282