Who is sponsoring NCT02235181?

NCT02235181 is sponsored by University of Edinburgh.

What drugs are being tested in NCT02235181?

Interventions in NCT02235181: Arabin Cervical Pessary.

What condition does NCT02235181 study?

NCT02235181 studies Twin Pregnancy With Antenatal Problem.

Is NCT02235181 still recruiting?

NCT02235181 is currently completed. Last updated 25 March 2020.

Last reviewed 2020-03-25 · How we verify

NCT02235181: STOPPIT-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

An Open Randomised Trial of the Arabin Pessary to Prevent Pre-term Birth in Twin Pregnancy

Completed NA Last updated 25 March 2020

What this trial tests

NA trial testing Arabin Cervical Pessary in Twin Pregnancy With Antenatal Problem in 2,228 participants. Completed in 31 October 2019.

Timeline

1 November 2014

Primary endpoint
31 July 2019

31 October 2019

Quick facts

Lead sponsor	University of Edinburgh
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	2,228
Start date	1 November 2014
Primary completion	31 July 2019
Estimated completion	31 October 2019
Sites	57 locations across Belgium, United Kingdom

Drugs / interventions tested

Arabin Cervical Pessary

Conditions studied

Twin Pregnancy With Antenatal Problem — all drugs for Twin Pregnancy With Antenatal Problem →

Sponsor

University of Edinburgh

Who can join

Adults 16 to 60, female only, with Twin Pregnancy With Antenatal Problem. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to determine whether the Arabin cervical pessary prevents preterm birth in women with a twin pregnancy and a short cervix.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis.
Norman JE, Norrie J, MacLennan G, Cooper D, et al · · 2021 · cited 30× · PMID 33780463 · DOI 10.1371/journal.pmed.1003506
Controversies about the Secondary Prevention of Spontaneous Preterm Birth.
Kyvernitakis I, Maul H, Bahlmann F. · · 2018 · cited 16× · PMID 29962517 · DOI 10.1055/a-0611-5337
Child outcomes after placement of a cervical pessary in women with a multiple pregnancy: A 4-year follow-up of the ProTWIN trial.
Simons NE, van de Beek C, van der Lee JH, Opmeer BC, et al · · 2019 · cited 14× · PMID 31032879 · DOI 10.1111/aogs.13630
Open randomised trial of the (Arabin) pessary to prevent preterm birth in twin pregnancy with health economics and acceptability: STOPPIT-2-a study protocol.
Norman JE, Norrie J, Maclennan G, Cooper D, et al · · 2018 · cited 8× · PMID 30530477 · DOI 10.1136/bmjopen-2018-026430
The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT.
Norman JE, Norrie J, MacLennan G, Cooper D, et al · · 2021 · cited 7× · PMID 34219633 · DOI 10.3310/hta25440

Verify or expand the search:

Other trials of Arabin Cervical Pessary

Trials testing the same drug.

NCT02901626 — A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix · Phase 3 · terminated

Other recruiting trials for Twin Pregnancy With Antenatal Problem

Currently open trials in the same condition.

NCT05894785 — External Cephalic Version (ECV) for Twins With Non-vertex Presenting Twin · NA · recruiting
NCT05144321 — Twin Pregnancy Cohort · active not recruiting
NCT05761769 — Twin Pregnancy: a Challenge for Patients, Families and Health Professionals · recruiting

Other University of Edinburgh trials

Trials by the same sponsor.

NCT07341126 — Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal · not yet recruiting
NCT07523997 — Imaging of Endometriosis With Total-body PET-CT (PET-Endo) · not yet recruiting
NCT07430540 — Optimising Colorectal Cancer Patient Pathways · NA · not yet recruiting
NCT07430527 — Secondary Care Colorectal Cancer Pathway Review · not yet recruiting
NCT07436026 — Latin America Network for Primary Palliative Care · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02235181 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
Last refreshed: 25 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02235181.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing