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NCT02233634: CADOS-CMR
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
NA trial testing Oxygen in Coronary Artery Disease in 36 participants. Completed in 2 November 2017.
2 November 2017
Quick facts
| Lead sponsor | Insel Gruppe AG, University Hospital Bern |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | factorial |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 36 |
| Start date | 1 October 2014 |
| Primary completion | 2 November 2017 |
| Estimated completion | 2 November 2017 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Oxygen — full drug profile →
- Hyperventilation Breath-hold (HVBH)
- HVBH with Oxygen
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Insel Gruppe AG, University Hospital Bern
Who can join
18 and older, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care. In recent studies a new innovative MRI-technique that can detect changes in oxygen supply of the heart was able to show that the administration of oxygen or fast breathing can decrease the blood supply of the arteries supplying the heart muscle with oxygen. Thus, the administration of oxygen may paradoxically impair the oxygen supply of the heart muscle. In this study the investigators want to investigate, whether the administration of exogenous oxygen via a mask alone and in combination with fast breathing leads to a decrease in oxygen supply in regions with already impaired blood supply by a narrowing of a coronary artery of the heart.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Feasibility of cardiovascular magnetic resonance to detect oxygenation deficits in patients with multi-vessel coronary artery disease triggered by breathing maneuvers.
Fischer K, Yamaji K, Luescher S, Ueki Y, et al · · 2018 · cited 38× · PMID 29730991 · DOI 10.1186/s12968-018-0446-y -
Effect of Hyperoxia on Myocardial Oxygenation and Function in Patients With Stable Multivessel Coronary Artery Disease.
Guensch DP, Fischer K, Yamaji K, Luescher S, et al · · 2020 · cited 26× · PMID 32089047 · DOI 10.1161/jaha.119.014739 -
Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.
Hawkins SM, Guensch DP, Friedrich MG, Vinco G, et al · · 2019 · cited 13× · PMID 31784617 · DOI 10.1038/s41598-019-54375-9
Verify or expand the search:
- PubMed search for NCT02233634
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Coronary Artery Disease
Currently open trials in the same condition.
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- NCT07420582 — Antegrade Autologous Blood Reinfusion After CPB · recruiting
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- NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
- NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting
Other Insel Gruppe AG, University Hospital Bern trials
Trials by the same sponsor.
- NCT06546384 — GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease · NA · not yet recruiting
- NCT07524049 — Giving Children a Voice in Paediatric Anaesthesia · not yet recruiting
- NCT07415668 — Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning · NA · not yet recruiting
- NCT07478536 — Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial) · not yet recruiting
- NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02233634 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Insel Gruppe AG, University Hospital Bern
- Last refreshed: 15 December 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02233634.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing