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NCT02215915: ULTIMATE
Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-comers" Coronary Lesions （ULTIMATE Trial）
NA trial testing Angiography in Coronary Artery Disease in 1,448 participants. Completed in 30 October 2020.
30 May 2017
Quick facts
| Lead sponsor | Nanjing First Hospital, Nanjing Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 1,448 |
| Start date | 1 August 2014 |
| Primary completion | 30 May 2017 |
| Estimated completion | 30 October 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- Angiography
- IVUS
- DES implantation
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Nanjing First Hospital, Nanjing Medical University
Who can join
18 and older, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A number of 1448 patients scheduled for elective percutaneous coronary intervention (PCI) with a native coronary stenosis suitable for DES implantation and IVUS imaging are openly randomized 1:1 to either IVUS guidance or angiographic guidance groups.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation: The ULTIMATE Trial.
Zhang J, Gao X, Kan J, Ge Z, et al · · 2018 · cited 420× · PMID 30261237 · DOI 10.1016/j.jacc.2018.09.013 -
3-Year Outcomes of the ULTIMATE Trial Comparing Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation.
Gao XF, Ge Z, Kong XQ, Kan J, et al · · 2021 · cited 220× · PMID 33541535 · DOI 10.1016/j.jcin.2020.10.001 -
Impact of intravascular ultrasound-guided drug-eluting stent implantation on patients with chronic kidney disease: Results from ULTIMATE trial.
Zhang J, Gao X, Ge Z, Han L, et al · · 2019 · cited 14× · PMID 31116913 · DOI 10.1002/ccd.28308 -
Procedural Characteristics of Intravascular Ultrasound-Guided Percutaneous Coronary Intervention and Their Clinical Implications.
Lee SY, Zhang JJ, Mintz GS, Hong SJ, et al · · 2022 · cited 8× · PMID 35861828 · DOI 10.1161/jaha.122.025258 -
Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI: A Meta-Analysis of Randomized Controlled Trials.
Ezenna C, Ibrahim S, Ramesh P, Ismayl M, et al · · 2025 · cited 3× · PMID 40829371 · DOI 10.1016/j.jacadv.2025.102076 -
Intravascular imaging-guided versus coronary angiography-guided percutaneous coronary intervention: Meta-analysis and trial sequential analysis of randomized controlled trials.
Li X, Zhong D, Yin Z, Liu H, et al · · 2026 · PMID 41686557 · DOI 10.1097/md.0000000000047193
Verify or expand the search:
- PubMed search for NCT02215915
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Nanjing First Hospital, Nanjing Medical University trials
Trials by the same sponsor.
- NCT07349979 — PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy · NA · not yet recruiting
- NCT07505056 — Jianpi Lishi Jiedu Granules for Prevention of Postoperative Recurrence in Colorectal Advanced Adenomas · Phase 3 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02215915 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nanjing First Hospital, Nanjing Medical University
- Last refreshed: 3 November 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02215915.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing