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A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis
Methyl aminolaevulinate photodynamic therapy (MAL-PDT) is advantageous in that it has few cosmetic side effects and minimises patient discomfort. However, its relatively low efficacy prevents its application to the treatment of actinic cheilitis(AC). Er:YAG ablative fractional laser (AFL) treatment removes the stratum corneum to increase MAL uptake and may improve efficacy. However, no studies have directly compared the efficacy of MAL-PDT with and without Er:YAG AFL in treating AC
Details
| Lead sponsor | Dong-A University |
|---|---|
| Phase | Phase 1 |
| Status | COMPLETED |
| Enrolment | 33 |
| Start date | 2012-01 |
| Completion | 2014-03 |
Conditions
- Actinic Cheilitis
Interventions
- Er:YAG AFL-PDT
- MAL-PDT
Primary outcomes
- Difference the efficacy between Er:YAG AFL-assisted MAL-PDT (Er:YAG AFL MAL-PDT) and standard MAL-PDT. — Efficacy was evaluated at 3 months and 12 months after treatment
Lesion response was classified as either complete (complete disappearance of the lesion) or incomplete (incomplete disappearance) on the basis of visual examination and palpation. The response of each lesion was clinically evaluated
Countries
South Korea