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NCT02195310

The Use of PrevenaTM on Clean Closed Sternal Midline Incisions in Subjects at High Risk for Surgical Site Occurrences.

Terminated NA Results posted Last updated 2 October 2024
What this trial tests

NA trial testing Prevena™ Incision Management System in Surgical Site Occurences After Sternotomy in 342 participants. Terminated before completion.

Timeline
12 November 2013
Primary endpoint
15 August 2016
17 October 2016

Quick facts

Lead sponsorSolventum US LLC
PhaseNA
StatusTerminated
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment342
Start date12 November 2013
Primary completion15 August 2016
Estimated completion17 October 2016
Sites13 locations across Austria, Netherlands, Germany

Drugs / interventions tested

Conditions studied

Sponsor

Solventum US LLC — full company profile →

Who can join

18 and older, any sex, with Surgical Site Occurences After Sternotomy or Wound Infection. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Surgical Site Infection (SSI) Rate Within 34 Days Postoperatively, Defined as Superficial, Deep, and Organ/Space Infections as Per CDC Guidelines. Primary · 30 ± 4 days

The SSI rate (in %) was calculated for each treatment arm as follows: SSI rate = \[Number of Subjects who experienced SSI\] / \[Number of Subjects Analyzed\] \* 100 Subjects included in the numerator for the SSI rate computation must have experienced an SSI post-surgery up to Day 30 (± 4 days). If a subject has the same SSI event on multiple occasions or experiences several events of other SSIs, the subject will be counted only once in the numerator for the first event

GroupValue95% CI
Prevena™ Incision Management System9.0
Conventional Sterile Wound Dressings10.4

Adverse events — posted to ClinicalTrials.gov

Reporting threshold: 5%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Prevena™ Incision Management System
Serious: 63/173 (36%)
Deaths:
Conventional Sterile Wound Dressings
Serious: 55/169 (33%)
Deaths:

Serious adverse events (88 terms)

ReactionSystemPrevena™ Incision Manageme…Conventional Sterile Wound…
Postoperative InfectionInfections and infestations
Wound DehiscenceInjury, poisoning and procedural complications
Cardiac TamponadeCardiac disorders
Atrioventricular BlockCardiac disorders
Cardiogenic ShockCardiac disorders
Cardiac FailureCardiac disorders
Haemodynamic InstabilityVascular disorders
Respiratory FailureRespiratory, thoracic and mediastinal disorders
Cerebrovascular AccidentNervous system disorders
Pericardial EffusionCardiac disorders
PneumoniaInfections and infestations
Renal InsufficiencyRenal and urinary disorders
Ventricular FailureCardiac disorders
Ventricular FibrillationCardiac disorders
Ventricular TachycardiaCardiac disorders
Myocardial InfarctionCardiac disorders
Septic ShockInfections and infestations
Groin InfectionInfections and infestations
Catheter Site InfectionInfections and infestations
InfectionInfections and infestations
Post Procedural HaemorrhageInjury, poisoning and procedural complications
Dislocation of SternumInjury, poisoning and procedural complications
HaematomaVascular disorders
Multi-Organ FailureGeneral disorders
Impaired HealingGeneral disorders
Other adverse events (16 terms — click to expand)

ReactionSystemPrevena™ Incision Manageme…Conventional Sterile Wound…
Atrial FibrillationCardiac disorders
Pleural EffusionRespiratory, thoracic and mediastinal disorders
AtelectasisRespiratory, thoracic and mediastinal disorders
Pericardial EffusionCardiac disorders
Wound DehiscenceInjury, poisoning and procedural complications
AnaemiaBlood and lymphatic system disorders
C-Reactive Protein IncreasedInvestigations
Psychotic DisorderPsychiatric disorders
Oedema PeripheralGeneral disorders
DiarrhoeaGastrointestinal disorders
DeliriumPsychiatric disorders
Wound DrainageSurgical and medical procedures
Post Procedural HaematomaInjury, poisoning and procedural complications
Postoperative InfectionInfections and infestations
Lung InfectionInfections and infestations
OedemaGeneral disorders

Most-reported serious reactions: Postoperative Infection, Wound Dehiscence, Cardiac Tamponade, Atrioventricular Block, Cardiogenic Shock, Cardiac Failure, Haemodynamic Instability, Respiratory Failure.

Data from ClinicalTrials.gov NCT02195310 adverse events section.

Sponsor's own description

The purpose of this study is to compare the use of Prevena™ Incision Management System (IMS) versus standard wound care for the incision in subjects undergoing a sternal midline incision (sternotomy). The subjects targetted for the study are at high risk for surgical complications (like infections) around the environment of the incision. The study is conducted in The Netherlands, Germany and Austria.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

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Other Solventum US LLC trials

Trials by the same sponsor.

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