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Potential for Improved Analgesia From Combined Medication for Superficial Pain
This research study is being done to assess if a combination of medications can enhance the relief of superficial pain (pain at the surface of the skin, such as sunburn pain). The investigators also want to find out if certain genes may be linked to individual differences in experienced efficacy of pain killers. The combination of medications under investigation is diclofenac and atropine. Diclofenac has been approved by the U.S. Food and Drug Administration (FDA) to treat pain. Atropine has been approved by the FDA to treat certain types of poisoning, heartbeat problems, and other diseases but atropine is not approved to treat pain. However, atropine has been used for many years in different European countries to treat painful conditions such as stomach cramps.This research study will compare diclofenac and atropine to placebo.
Details
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 100 |
| Start date | 2014-04 |
| Completion | 2017-06 |
Conditions
- Pain
Interventions
- Diclofenac and Atropine combination drug
- Placebo
Primary outcomes
- Pain Scores on Standardized Experimental Pain Testing — baseline and 1 hour pain measurement
Pain scores on standardized experimental pain testing, with collection of Visual analog scales (VAS) on a 0-100 scale 0 (no pain)- 100 (worst pain imaginable) Higher values represent a worse outcome (more pain)
Countries
United States