Comparison of Neutral Protamine Hagedorn (NPH) and Lantus Based Insulin Regimen in the Management of Hypoglycemia in the Hospitalized Patients in Noncritical Care Setting

NCT02189395 Phase 4 TERMINATED

The goal of the current study is to determine difference in glycemic control between traditional split mix regimen with Neutral Protamine Hagedorn (NPH) and regular insulin vs basal bolus regimen with glargine and humalog in a population of type 2 diabetes commonly encountered in the investigators county hospital setting which include newly diagnosed type 2 patients and patients on relatively high dose of insulin (dose \>0.4 units/kg body weight. Primary outcome of the study is to determine differences in glycemic control between treatment group as measured by the mean daily blood glucose. Secondary outcome is to measure number of hypoglycemic events, number of severe hypoglycemia and length of hospital stay.

Details

Lead sponsor	Riverside University Health System Medical Center
Phase	Phase 4
Status	TERMINATED
Enrolment	52
Start date	2013-04
Completion	2017-04

Conditions

• Type 2 Diabetes Mellitus

Interventions

• NPH and regular insulin
• glargine and humalog

Primary outcomes

• difference in glycemic control between treatment groups as measured by the mean daily blood glucose — Duration of hospital stay, up to 24 weeks
  Primary outcome of the study is to determine differences in glycemic control between treatment group as measured by the mean daily blood glucose

Countries

United States