Effects of Anesthetic Blockades on Pain Modulation in Migraine

NCT02188394 Phase 2 COMPLETED

Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies. The aim of this study is to evaluate the short-term clinical efficacy of GON anaesthetic blockades in chronic migraine and to analyze their effect on pressure pain thresholds (PPTs) in different areas. We hypothesize that those patients receiving real GON anesthetic blockade will receive greater improvements in pain nociception. We will conduct a double-blind, randomized, parallel and placebo-controlled clinical trial where one group will be treated with bilateral GON blockade with bupivacaine 0,5% and the other group will be treated with placebo.

Details

Lead sponsor	César Fernández-de-las-Peñas
Phase	Phase 2
Status	COMPLETED
Enrolment	36
Start date	2014-07
Completion	2016-01

Conditions

• Chronic Migraine
• Pain

Interventions

• Anesthetic blockades with bupivacaine
• Isotonic saline injection

Primary outcomes

• Changes in the number of days with moderate/intense migraine — Baseline (1 week before) and 1 week after intervention
  A headache diary will register the number of days with moderate/intense migraine. Moderate/intense migraine is considered a headache with an intensity level over 4 points on a numerical pain rate scale (NPRS, 0-10)

Countries

Spain