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NCT02182492
Comparison of Different Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis Patients After Endoscopic Sinus Surgery
NA trial testing Clarithromycin in Chronic Rhinosinusitis in 187 participants. Completed in 1 June 2016.
1 December 2015
Quick facts
| Lead sponsor | Zheng Liu |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 187 |
| Start date | 1 January 2014 |
| Primary completion | 1 December 2015 |
| Estimated completion | 1 June 2016 |
| Sites | 1 location across China |
Drugs / interventions tested
- Clarithromycin (clarithromycin) — full drug profile →
- Glucocorticoid — full drug profile →
Conditions studied
- Chronic Rhinosinusitis — all drugs for Chronic Rhinosinusitis →
- Endoscopic Sinus Surgery — all drugs for Endoscopic Sinus Surgery →
Sponsor
Zheng Liu — full company profile →
Who can join
Adults 16 to 70, any sex, with Chronic Rhinosinusitis or Endoscopic Sinus Surgery. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Total Subjective Symptoms Visual Analog Scores (VAS)
Time frame: Scores will be recorded just before ESS and at 1-, 3-, 6- and 12-month follow-up visit.
The treatment will begin one week after ESS. Symptoms visual analog scores (VAS) were recorded just before ESS and at 1-, 3-, 6- and 12-month follow-up visit. All of the patients were assessed by using symptom questionnaire after enrollment and at follow-up visits. Subjective symptoms were scored by patients on a VAS of 0-10, with 0 being "no complaint whatsoever" and 10 being "the worst imaginabl
Sponsor's own description
Endoscopic sinus surgery (ESS) is widely considered to be the gold standard in the surgical management of chronic rhinosinusitis (CRS) that has failed maximal medical therapy. Nevertheless, the postoperation medical therapy was considered as a crucial procedure for the success of ESS. Both glucocorticoids and macrolide antibiotics have been recommended for the treatment of CRS, but their effect as postoperation medical therapies of ESS need more clinical data to clarify. The purpose of this prospective, randomized,study is to determine the effect of glucocorticoids and macrolide antibiotics for the postoperation medical therapy of ESS in different subtypes of CRS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT02182492
- Europe PMC full search
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Related trials
Other trials of Clarithromycin
Trials testing the same drug.
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- NCT07086937 — Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children · NA · completed
- NCT06514274 — Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Era · Phase 4 · completed
- NCT06551623 — Drug-Drug Interactions Between TNP-2198 and Midazolam, Clarithromycin · Phase 1 · completed
- NCT06576882 — 7 Days vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication · Phase 3 · completed
Other recruiting trials for Chronic Rhinosinusitis
Currently open trials in the same condition.
- NCT06920576 — Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal En · Phase 1, PHASE2 · active not recruiting
- NCT06457100 — Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Sur · Phase 1, PHASE2 · active not recruiting
- NCT07340411 — Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis · Phase 2 · recruiting
- NCT05883462 — Paclitaxel-Coated Nasal Balloon for the Treatment of Recurrent Chronic Rhinosinusitis With or Without Nasal Polyps (FIH) · EARLY_PHASE1 · active not recruiting
- NCT05935683 — Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis · recruiting
Other Zheng Liu trials
Trials by the same sponsor.
- NCT07139639 — Evidence-Based Evaluation of Classic Herb Pair (Chuanxiong Rhizoma and Salviae Miltiorrhizae) for Preventing Recurrence · EARLY_PHASE1 · not yet recruiting
- NCT06462417 — Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis · NA · recruiting
- NCT06474923 — Multimodal Data-assisted Primary Screening for Allergic Rhinitis Based on Voice Recognition and Face Recognition · completed
- NCT06198894 — Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms · NA · unknown
- NCT04852562 — The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02182492 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zheng Liu
- Last refreshed: 21 September 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02182492.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing