NCT02177643 is a Phase 2 clinical trial of Diacerein in Diabetes-Related Complications, sponsored by University of Campinas, Brazil.

Who is sponsoring NCT02177643?

NCT02177643 is sponsored by University of Campinas, Brazil.

What drugs are being tested in NCT02177643?

Interventions in NCT02177643: Diacerein, Placebo.

What condition does NCT02177643 study?

NCT02177643 studies Diabetes-Related Complications, Diabetes Mellitus, Type 2, Insulin Resistance.

Is NCT02177643 still recruiting?

NCT02177643 is currently status unknown. Last updated 15 September 2015.

Last reviewed 2015-09-15 · How we verify

NCT02177643

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Diacerein in the Metabolic Control of Patients With Diabetes Mellitus Type 2 and Secondary Failure to Metformin

Status unknown Phase 2 Last updated 15 September 2015

What this trial tests

Phase 2 trial testing Diacerein in Diabetes-Related Complications in 60 participants. Status unknown.

Timeline

1 January 2013

Primary endpoint
1 August 2016

Quick facts

Lead sponsor	University of Campinas, Brazil
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	60
Start date	1 January 2013
Primary completion	1 August 2016
Sites	3 locations across Brazil

Drugs / interventions tested

Diacerein (DIACEREIN) — full drug profile →
Placebo

Conditions studied

Diabetes-Related Complications — all drugs for Diabetes-Related Complications →
Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
Insulin Resistance — all drugs for Insulin Resistance →

Sponsor

University of Campinas, Brazil

Who can join

Adults 18 to 65, any sex, with Diabetes-Related Complications or Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Fasting Glucose Concentration
Time frame: Baseline, 12 weeks
Fasting Insulin Concentration
Time frame: Baseline, 12 weeks
HbA1c - glycated haemoglobin
Time frame: Baseline, 12 weeks
Inflammatory Activity Profile
Time frame: Baseline, 12 weeks
TNFα IL6 IL1β C-Reactive Protein (CRP)
Lipid Panel
Time frame: Baseline, 12 weeks
Hepatic Function Panel
Time frame: Baseline, 12 weeks

Sponsor's own description

Considering that, Diacerein is on the market for almost 20 years, being used continuously in elderly patients with osteoarthritis without present significant side effects, and considering the anti-hyperglycemic effect and the improvement in the insulin resistance observed in animal models of type 2 diabetes and in a previously study from Mexico. The aim of our study is to investigate the effect of Diacerein, a medication with anti-osteoarthritic properties and moderately analgesic activity, anti-inflammatory and antipyretic, which demonstrates inhibit properties for the synthesis of pro-inflammatory cytokines such as interleukin 1 (IL-1). Administered for 12 weeks and the effect in the glycemic and metabolic control in patients with diabetes mellitus 2 and secondary failure to metformin treatment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Advances in Drug Delivery Science for Diacerein: Strategies to Enhance Solubility, Bioavailability, and Pharmacokinetic Performance.
Naseri M, Ghobakhlou S, Heidarizade N, Akbari ME, et al · · 2025 · PMID 41471053 · DOI 10.3390/pharmaceutics17121539

Verify or expand the search:

Other trials of Diacerein

Trials testing the same drug.

NCT07352306 — Topical Diacerein in Psoriasis Vulgaris · Phase 4 · not yet recruiting
NCT05226754 — Study Design of the Diacerein in Patients With Covid-19 · Phase 2 · unknown
NCT04351100 — Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients · completed
NCT03404479 — Trial to Evaluate Efficacy and Safety of Combination of Diacerein and Celecoxib Administered in Patients With Knee OA · Phase 4 · unknown
NCT02242149 — Efficacy Study of Diacerein on Glycemic Control and Liver Fat in Type 2 Diabetes Subjects · Phase 3 · completed

Other recruiting trials for Diabetes-Related Complications

Currently open trials in the same condition.

NCT06979440 — Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression · recruiting

Other University of Campinas, Brazil trials

Trials by the same sponsor.

NCT06929676 — Assessment of Tooth Mobility After Non-surgical Periodontal Treatment Followed by Tooth Splinting · NA · enrolling by invitation
NCT07456163 — Influence of Zirconia Abutments on Peri-Implant Tissues in Single-Tooth Restorations · NA · recruiting
NCT06884475 — Evaluation of Implantoplasty in the Treatment of Peri-Implantitis. · NA · active not recruiting
NCT06450327 — Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus") Syndrome? · recruiting
NCT06600867 — Method for Measuring Dental Mobility and Displacement Force · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02177643 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Campinas, Brazil
Last refreshed: 15 September 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02177643.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing