NCT02171273 is a NA clinical trial of Circadian Disruption in Aging, sponsored by Brigham and Women's Hospital.

Who is sponsoring NCT02171273?

NCT02171273 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT02171273?

Interventions in NCT02171273: Circadian Disruption, Sleep Restriction, Control.

What condition does NCT02171273 study?

NCT02171273 studies Aging, Sleep Restriction, Circadian Disruption.

Is NCT02171273 still recruiting?

NCT02171273 is currently completed. Last updated 20 August 2019.

Last reviewed 2019-08-20 · How we verify

NCT02171273

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism

Completed NA Last updated 20 August 2019

What this trial tests

NA trial testing Circadian Disruption in Aging in 21 participants. Completed in 1 April 2019.

Timeline

31 March 2014

Primary endpoint
1 April 2019

1 April 2019

Quick facts

Lead sponsor	Brigham and Women's Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	21
Start date	31 March 2014
Primary completion	1 April 2019
Estimated completion	1 April 2019
Sites	1 location across United States

Drugs / interventions tested

Circadian Disruption
Sleep Restriction
Control

Conditions studied

Aging — all drugs for Aging →
Sleep Restriction — all drugs for Sleep Restriction →
Circadian Disruption — all drugs for Circadian Disruption →

Sponsor

Brigham and Women's Hospital

Who can join

Adults 21 to 70, any sex, with Aging or Sleep Restriction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The overall objectives of the proposed study are to examine the consequences of chronic circadian disruption and chronic sleep restriction on metabolic function in healthy adults.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Fasting blood triglycerides vary with circadian phase in both young and older people.
Yuan RK, Zitting KM, Wang W, Buxton OM, et al · · 2020 · cited 20× · PMID 32519460 · DOI 10.14814/phy2.14453
Chronic circadian disruption on a high-fat diet impairs glucose tolerance.
Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, et al · · 2022 · cited 19× · PMID 35150732 · DOI 10.1016/j.metabol.2022.155158
Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance.
Yuan RK, Zitting KM, Duffy JF, Vujovic N, et al · · 2021 · cited 16× · PMID 34744800 · DOI 10.3389/fphys.2021.764737
Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance.
Xin Q, Yuan RK, Zitting KM, Wang W, et al · · 2022 · cited 10× · PMID 35218665 · DOI 10.1093/sleep/zsac046

Verify or expand the search:

Other recruiting trials for Aging

Currently open trials in the same condition.

NCT02831335 — Technical Development of Multi-Parametric Renocerebral MRI · recruiting
NCT07099053 — Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging · recruiting
NCT07504068 — Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in · NA · recruiting
NCT07525453 — Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults · NA · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other Brigham and Women's Hospital trials

Trials by the same sponsor.

NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02171273 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 20 August 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02171273.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing