A Prospective, Randomized, Single-Blind Study to Evaluate the Efficacy of Transversus Abdominis Plane Versus Paravertebral Regional Blockade in Patients Undergoing Laparoscopic Colectomy

NCT02164929 NA TERMINATED Results posted

The purpose of this study is to assess the effectiveness of transversus abdominal plane (TAP) block, thoracic epidural or paravertebral block (PVB) for controlling postoperative pain when compared with opioid you self-administer in your vein using a PCA device. The primary outcome will be postoperative opioid consumption within 24 hours after surgery. A total of 120 subjects will be randomized in a 1:1:1:1 ratio to receive a TAP block, PVB, TEA or no block (PCA alone).Patients in all groups will be cared for using an established enhanced recovery after surgery (ERAS) pathway incorporating a multimodal analgesic regimen using IV acetaminophen and postoperative PCA fentanyl.

Details

Lead sponsor	Duke University
Phase	NA
Status	TERMINATED
Enrolment	17
Start date	2013-12
Completion	2015-03

Conditions

• Laparoscopic Colorectal Resection

Interventions

• TAP block
• Epidural
• Paravertebral block
• Acetaminophen 1g IV
• Dexamethasone 4mg
• Midazolam up to 2mg
• Propofol 1-2.5 mg/kg
• Sevoflurane to keep a bispectral index of between 40-60
• Local infiltration with 10 mL of plain ropivacaine 0.25%
• Lidocaine

Primary outcomes

• Postoperative Opioid Consumption — 24 hours after surgery
  If opioid other than fentanyl is used, the dose will be converted to morphine equivalent.

Countries

United States