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Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls (APPLE)
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance. The investigators will assess hepatic glucose release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial state to determine if alterations in the processes contribute to hepatic steatosis. Participants will be overweight, sedentary girls with or without PCOS. Those with PCOS will either be medication naive, or must be taking metformin or combined oral contraceptives (COCPs) for a period of at least 6 months prior to study procedures.
Details
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | COMPLETED |
| Enrolment | 92 |
| Start date | 2014-08 |
| Completion | 2022-12 |
Conditions
- Hepatic Steatosis
- Polycystic Ovarian Syndrome
- Obesity
Interventions
- Byetta 5Mcg Pen Injection
Primary outcomes
- Hepatic Glucose Release — Measured up to 4 months from enrollment
Hepatic glucose release will be measured by the rate of appearance of a glucose tracer. Glucose rate of appearance reflects the amount of glucose being release by primarily the liver during fasting. A higher glucose rate of appearance is often seen with dysglycemia
Countries
United States