NCT02154009

Clinical Autonomic Disorders: A Training Protocol

Terminated Last updated 8 April 2021

What this trial tests

trial in Posttraumatic Stress Disorder in 21 participants. Terminated before completion.

Timeline

5 June 2014

Primary endpoint
15 August 2019

7 April 2021

Quick facts

Lead sponsor	National Institute of Neurological Disorders and Stroke (NINDS)
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	21
Start date	5 June 2014
Primary completion	15 August 2019
Estimated completion	7 April 2021
Sites	1 location across United States

Conditions studied

• Posttraumatic Stress Disorder — all drugs for Posttraumatic Stress Disorder →
• Pseudopheochromocytoma — all drugs for Pseudopheochromocytoma →
• Healthy Volunteers — all drugs for Healthy Volunteers →
• Neurocardiogenic Syncope — all drugs for Neurocardiogenic Syncope →

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Who can join

2 and older, any sex, with Posttraumatic Stress Disorder or Pseudopheochromocytoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia. Researchers want to learn more about dysautonomias and train doctors to learn how to better diagnose them.

Objectives:

* To allow people with autonomic disorders to be evaluated.
* To help fellows in the NIH Autonomic Disorders fellowship program see a variety of diseases in their training.

Eligibility:

* People age 18 and older with dysautonomia; children over age 2 if they might benefit
* Healthy adult volunteers

Design:

* Participants will have different procedures depending on their symptoms. They will have one or more visits. They will have some but not all of the tests below.
* Participants will have a medical history and physical exam. They may be tested for problems thinking. They may complete a symptom questionnaire. They may have their temperature and blood pressure taken.
* Participants may have an intravenous line placed. A needle will guide a thin plastic tube into an arm vein.
* Participants may have blood drawn several times. They may give a urine sample.
* Participants may have an electrocardiogram.
* How much blood a participant s heart is pumping and/or how much blood is flowing through their arm may be measured. The total amount of blood in their bloodstream may be measured.
* Participants may have their ability to sweat and/or sense of smell tested.
* Breathing, bowel sounds, and/or body functions may be monitored.
* Pupil size, response to environmental temperature changes, and/or breathing may be measured.
* Participants may have a bladder ultrasound.
* Small pieces of skin may be taken for study.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.