NCT02150889: TrainMeUpMN

Training Effects on Fuel Metabolism

Active, enrolled NA Last updated 8 January 2026

What this trial tests

NA trial testing Running Program in Healthy Subjects in 64 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 July 2014

Primary endpoint
30 December 2018

31 December 2026

Quick facts

Lead sponsor	University of Minnesota
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	64
Start date	1 July 2014
Primary completion	30 December 2018
Estimated completion	31 December 2026
Sites	1 location across United States

Drugs / interventions tested

• Running Program
• Yoga Program

Conditions studied

• Healthy Subjects — all drugs for Healthy Subjects →
• Lean Trained Subjects — all drugs for Lean Trained Subjects →
• Overweight and Obesity — all drugs for Overweight and Obesity →

Sponsor

University of Minnesota

Who can join

Adults 18 to 40, any sex, with Healthy Subjects or Lean Trained Subjects. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental.

Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program.

Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Acute aerobic exercise reveals that FAHFAs distinguish the metabolomes of overweight and normal-weight runners.
   Nelson AB, Chow LS, Stagg DB, Gillingham JR, et al · · 2022 · cited 19× · PMID 35192550 · DOI 10.1172/jci.insight.158037
2. DXA-Determined Regional Adiposity Relates to Insulin Resistance in a Young Adult Population with Overweight andObesity.
   Bantle AE, Bosch TA, Dengel DR, Wang Q, et al · · 2019 · cited 10× · PMID 30064815 · DOI 10.1016/j.jocd.2018.06.001
3. 56^th EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.
   · 2020 · cited 9× · PMID 32840677 · DOI 10.1007/s00125-020-05221-5
4. V_E/VCO₂ slope in lean and overweight women and its relationship to lean leg mass.
   Keller-Ross ML, Chantigian DP, Evanoff N, Bantle AE, et al · · 2018 · cited 5× · PMID 30426069 · DOI 10.1016/j.ijcha.2018.10.009
5. The impact of high BMI on acute changes in body composition following 90 minutes of running.
   Brayton SH, Bosch TA, Bantle AE, Hodges JS, et al · · 2018 · PMID 31380465 · DOI 10.1080/2331205x.2018.1502960