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Intravenous Dexmedetomidine For The Quaity Of Emergence From General Anesthesia: A Dose-Finding Study
In a prospective randomized clinical trial involving adult patients undergoing elective surgery under general anesthesia, the investigators will enroll 216 patients, and evaluate 3 doses of prophylactic dexmedetomidine as a means to reduce postoperative shivering and quality of emergence from anesthesia versus placebo.
Details
| Lead sponsor | American University of Beirut Medical Center |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 216 |
| Start date | 2009-09 |
| Completion | 2015-09 |
Conditions
- Anesthesia Recovery
- Anesthesia Emergence
- Shivering
- Postoperative Recovery
Interventions
- dexmedetomidine 0.25 µg/kg IV
- dexmedetomidine 0.5 µg/kg IV
- dexmedetomidine 1 µg/kg IV
- Placebo Comparator
Primary outcomes
- Postanaesthetic shivering incidence and score — change from baseline every 10 minutes up to 1 hour post-operatively
- Quality of emergence from anesthesia — Change from baseline every 5 minutes till extubation
The anesthesiologist blinded to the group allocation will assess patients for coughing, hypertension, tachycardia, limb movement during extubation
Countries
Lebanon