NCT02138344

Assessment of Neuropathic Pain

Completed Last updated 17 January 2025

What this trial tests

trial in Spinal Cord Injury + Peripheral Nerve Diseases in 600 participants. Completed in 27 September 2024.

Timeline

1 April 2006

Primary endpoint
27 September 2024

27 September 2024

Quick facts

Lead sponsor	University of Zurich
Status	Completed
Study type	OBSERVATIONAL
Enrollment	600
Start date	1 April 2006
Primary completion	27 September 2024
Estimated completion	27 September 2024
Sites	1 location across Switzerland

Conditions studied

• Spinal Cord Injury + Peripheral Nerve Diseases — all drugs for Spinal Cord Injury + Peripheral Nerve Diseases →

Sponsor

University of Zurich

Who can join

Adults 18 to 75, any sex, with Spinal Cord Injury + Peripheral Nerve Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases. The functionality of the pain pathway in humans as well as its plastic changes following SCI can be assessed in vivo by surface electrophysiological recordings and functional magnetic resonance imaging after noxious heat stimulation of the skin. Aims: a) establishing a clinically applicable assessment of the pain pathway and characterizing its changes as a consequence of SCI and in peripheral nerve diseases in an objective manner, b) characterizing plastic changes in the pain pathway in SCI patients with neuropathic pain and in patients with peripheral nerve diseases and relating them to the development of neuropathic pain syndromes.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes.
   Jutzeler CR, Rosner J, Rinert J, Kramer JL, et al · · 2016 · cited 38× · PMID 27708413 · DOI 10.1038/srep34660
2. Supraspinal nociceptive networks in neuropathic pain after spinal cord injury.
   Huynh V, Lütolf R, Rosner J, Luechinger R, et al · · 2021 · cited 29× · PMID 34132441 · DOI 10.1002/hbm.25401
3. Improved acquisition of contact heat evoked potentials with increased heating ramp.
   De Schoenmacker I, Archibald J, Kramer JLK, Hubli M. · · 2022 · cited 21× · PMID 35042939 · DOI 10.1038/s41598-022-04867-y
4. Indicators of central sensitization in chronic neuropathic pain after spinal cord injury.
   Lütolf R, Rosner J, Curt A, Hubli M. · · 2022 · cited 20× · PMID 36008094 · DOI 10.1002/ejp.2028
5. Normative data of contact heat evoked potentials from the lower extremities.
   Rosner J, Hostettler P, Scheuren PS, Sirucek L, et al · · 2018 · cited 18× · PMID 30030450 · DOI 10.1038/s41598-018-29145-8
6. Descending pain modulatory efficiency in healthy subjects is related to structure and resting connectivity of brain regions.
   Huynh V, Lütolf R, Rosner J, Luechinger R, et al · · 2022 · cited 14× · PMID 34863962 · DOI 10.1016/j.neuroimage.2021.118742
7. Anti- and Pro-Nociceptive mechanisms in neuropathic pain after human spinal cord injury.
   Lütolf R, De Schoenmacker I, Rosner J, Sirucek L, et al · · 2022 · cited 13× · PMID 36000307 · DOI 10.1002/ejp.2029
8. Central sensitization in CRPS patients with widespread pain: a cross-sectional study.
   De Schoenmacker I, Mollo A, Scheuren PS, Sirucek L, et al · · 2023 · cited 12× · PMID 36946277 · DOI 10.1093/pm/pnad040