Effect of Non-steroid Anti-inflammatory Drug on Travoprost-induced Conjunctival Hyperemia and Intraocular Pressure Reduction in Normal Eyes (ENTICHIR)

NCT02136589 Phase 4 COMPLETED

PG-analogues induce hyperemia as one of side effects in addition to IOP reduction. IOP reduction is caused by direct FP receptor stimulation, but the cause of hyperemia is not clarified. Because FP receptor stimulation induce intrinsic production of PGs, hyperemia or IOP reduction may be due to secondary induced PGs. Thus, pretreatment with NSAID may affect the PG-analogue induced hyperemia or IOP reduction.

Details

Lead sponsor	Tokyo University
Phase	Phase 4
Status	COMPLETED
Enrolment	40
Start date	2008-09
Completion	2008-12

Conditions

• Hyperemia
• Intraocular Pressure

Interventions

• dicrofenac and travoprost

Primary outcomes

• IOP reduction — 1 day
  effect of NSAID on IOP reduction by travoprost