Effect of Low Childhood Socioeconomic Status (SES) on Adult Endothelial Function and Nitric Oxide Bioavailability in Vivo and ex Vivo (NO-Stress)

NCT02115724 NA ACTIVE_NOT_RECRUITING

Cardiovascular disease is the leading cause of death in the United States. Other studies have shown that stress, early in life, could be a risk factor for cardiovascular disease, later in life. This study will look at the effect of early life stressors on your cardiovascular health.

Details

Lead sponsor	Augusta University
Phase	NA
Status	ACTIVE_NOT_RECRUITING
Enrolment	74
Start date	2014-04
Completion	2027-01

Conditions

• Cardiovascular Disease

Interventions

• Antioxidant cocktail
• Biopsy
• Placebo
• NMD; 0.4mg sub-lingual nitroglycerin spray

Primary outcomes

• Acute Change in Flow mediated dilation — Change from baseline (2 hours)
  Flow-Mediated Dilation will be determined at baseline and 2 hours following acute antioxidant treatment

Countries

United States