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Reduction of C-Difficile Infection Using Fecal Microbiota Transplant (FMT)
Clostridium-difficile (C-difficile) is a gram positive anaerobic spore-forming bacterium that can lead to severe diarrhea and pseudomembranous colitis. According to Schroeder (2005), there are approximately 3 million cases annually with a mortality rate of 1-2.5 %. It is most often associated with overuse of antibiotics. According to Bartlett \& Gerding (2008), 15-25% of anti-microbial-associated diarrhea is caused by C-difficile. The purpose of this study is to determine if donor fecal microbiota transplant via colonoscopy reduces refractory C-difficile infection better than current routine methods such as continued antibiotic treatment. Specifically, we hypothesize that fecal microbiota transplant via colonoscopy will result in a higher C-difficile cure rate in affected patients versus care as usual in a retrospective cohort.
Details
| Lead sponsor | Providence Holy Cross Medical Center |
|---|---|
| Phase | Phase 1 |
| Status | UNKNOWN |
| Enrolment | 10 |
| Start date | 2014-04 |
| Completion | 2015-06 |
Conditions
- C-difficile
Interventions
- Donor microbiota applied via colonoscopy.
Primary outcomes
- Negative c-difficile test — 30 days
Enrolled patients will test negative for c-difficile following application of the study intervention
Countries
United States