Who is sponsoring NCT02111382?

NCT02111382 is sponsored by University of Brasilia.

What drugs are being tested in NCT02111382?

Interventions in NCT02111382: CV4 Cranial (4th ventricle technique) Osteopathic Manipulative, CV4 (4th ventricle technique) manual therapy sham technique.

What condition does NCT02111382 study?

NCT02111382 studies Low Back Pain.

Is NCT02111382 still recruiting?

NCT02111382 is currently withdrawn. Last updated 15 August 2023.

Last reviewed 2023-08-15 · How we verify

NCT02111382

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Electroencephalography Activity in Individuals With Nonspecific Chronic Low Back Pain After Cranial Osteopathic Manipulative Treatment

Withdrawn NA Last updated 15 August 2023

What this trial tests

NA trial testing CV4 Cranial (4th ventricle technique) Osteopathic Manipulative in Low Back Pain. Withdrawn.

Timeline

31 January 2018

Primary endpoint
30 June 2018

31 December 2018

Quick facts

Lead sponsor	University of Brasilia
Phase	NA
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Start date	31 January 2018
Primary completion	30 June 2018
Estimated completion	31 December 2018
Sites	1 location across Brazil

Drugs / interventions tested

CV4 Cranial (4th ventricle technique) Osteopathic Manipulative
CV4 (4th ventricle technique) manual therapy sham technique

Conditions studied

Low Back Pain — all drugs for Low Back Pain →

Sponsor

University of Brasilia

Who can join

18 and older, any sex, with Low Back Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Osteopathic medicine is based on a diagnostic and therapeutic system to treat tissue mobility/ motility dysfunctions in general, using different approaches (depending on the target tissue) known as osteopathic manipulative treatment. Among all the available techniques those ones addressed to the cranial field are most questioned because of the lack of scientific evidence; but the compression of the 4th ventricle technique has been largely studied in clinical trials. Studies have shown that the technique may affect both central and autonomous nervous system, modulating some reflexes (Traube-Hering baro signal), and modifying brain cortex electrical activity through central sensitization in subjects with chronic low back pain. Thus, investigators hypothesize that the compression of the 4th ventricle may modulate peak alpha frequency (electroencephalographic assessment) and promote physical relaxation in subjects in vigil.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Immediate changes in electroencephalography activity in individuals with nonspecific chronic low back pain after cranial osteopathic manipulative treatment: study protocol of a randomized, controlled crossover trial.
Martins WR, Diniz LR, Blasczyk JC, Lagoa KF, et al · · 2015 · cited 7× · PMID 26165865 · DOI 10.1186/s12906-015-0732-2

Verify or expand the search:

Other recruiting trials for Low Back Pain

Currently open trials in the same condition.

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Other University of Brasilia trials

Trials by the same sponsor.

NCT07453485 — Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Function in Achilles Tendon Disorders · NA · recruiting
NCT07515989 — Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnos · NA · recruiting
NCT06651099 — Trial-based Economic Evaluation of a Mobile Health Intervention for Individuals With Chronic Non-specific Low Back Pain · NA · recruiting
NCT06318728 — Musculotendinous Adaptations in High and Low- Performance Triathletes · unknown
NCT06266845 — Efficacy of Gamification With Escape-Room for Arrhythmia Identification in Critical Patients · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02111382 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Brasilia
Last refreshed: 15 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02111382.

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