NCT02100800: EMPHYREM

Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences

Completed NA Last updated 9 February 2022

What this trial tests

NA trial testing MR and CT measurements of emphysema quantification in Emphysema in 33 participants. Completed in 13 July 2016.

Timeline

23 May 2014

Primary endpoint
13 July 2016

13 July 2016

Quick facts

Lead sponsor	University Hospital, Bordeaux
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	33
Start date	23 May 2014
Primary completion	13 July 2016
Estimated completion	13 July 2016
Sites	1 location across France

Drugs / interventions tested

• MR and CT measurements of emphysema quantification

Conditions studied

• Emphysema — all drugs for Emphysema →

Sponsor

University Hospital, Bordeaux

Who can join

40 and older, any sex, with Emphysema. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Emphysema is a major pathological feature of Chronic Obstructive Pulmonary Disease (COPD). Non-invasive assessment of emphysema is a crucial issue for the phenotype and follow-up of COPD patients. Currently, CT is the method of reference to evaluate and quantify emphysema but it remains a radiation-based technique. Magnetic Resonance Imagery (MRI) with ultrashort echo time (UTE) pulse sequences is a promising non-ionizing alternative for lung imaging. Our objective is to evaluate emphysema in COPD patients using CT and MR-UTE, and to test the agreement between both techniques.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Quantification of Lung Ventilation Using Four-Dimensional Dynamic Ultrashort Echo Time MRI for Differentiating Preserved Ratio Impaired Spirometry From Non-Chronic Obstructive Pulmonary Disease Subjects.
   Zhang Z, Li J, Ding Z, Xia Y, et al · · 2025 · PMID 40906510 · DOI 10.1002/jmri.70064