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Prospective Randomized Trial on the Effect of DHEA Administration in Women With Poor Ovarian Reserve Undergoing Controlled Ovarian Stimulation for IVF. Impact on Stimulation Characteristics and and Pregnancy Outcome.
Poor responders to ovarian stimulation represents one of the most frustrating problems in reproductive medicine. The investigators hypothesize that ovarian response of those patients could improve by treating these patients with 25 mg DHEA tid for 12 weeks prior to stimulation.
Details
| Lead sponsor | University of Athens |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | UNKNOWN |
| Enrolment | 50 |
| Start date | 2014-10 |
| Completion | 2015-12 |
Conditions
- Efficacy of DHEA
- Pregnancy Rate
- Diminished Ovarian Reserve
- Changes in AMH
Interventions
- gonadotropins plus DHEA
- Gonadotropins
Primary outcomes
- clinical pregnancy — At 12 weeks after DHEA administration and at 18 months
At the completion of the ovarian stimulation patients that will proceed to transfer and have a positive pregnancy test will have sonographic evaluation for confirmation of clinical pregnancy.