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NCT02057497
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms
trial in Prediabetes. Withdrawn.
10 October 2017
Quick facts
| Lead sponsor | Profil Institut für Stoffwechselforschung GmbH |
|---|---|
| Status | Withdrawn |
| Study type | OBSERVATIONAL |
| Start date | 9 October 2017 |
| Primary completion | 10 October 2017 |
| Estimated completion | 10 October 2017 |
Conditions studied
- Prediabetes — all drugs for Prediabetes →
- Diabetes Type 1 — all drugs for Diabetes Type 1 →
- Diabetes Type 2 — all drugs for Diabetes Type 2 →
Sponsor
Profil Institut für Stoffwechselforschung GmbH — full company profile →
Who can join
18 and older, any sex, with Prediabetes or Diabetes Type 1. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
G (guanine nucleotide binding) proteins associating with G protein-coupled receptors (GPCR) are key players in the pathogenesis of obesity and diabetes and are targets of pharmacotherapeutic inter-ventions. In addition, G proteins binding to GPCRs either directly or permissively determine the efficacy of lifestyle interventions and drugs aiming at weight management and diabetes treatment. Polymor-phisms of the fat mass and obesity-related protein (FTO) gene have been also well characterised and linked to energy intake, body fat mass as well as CVD risk and the susceptibility to weight-reducing interventions. Stratifying patients according to G protein and FTO-related genotyping may enable a more accurate prediction of individual disease courses and responses to therapeutic interventions in terms of safety and tolerability as well as efficacy. Although the objectives primarily refer to the analysis of G pro-tein and FTO-related genotypes, also other genes of potential relevance for the evolution of obesity and/ or diabetes and the response to lifestyle and pharmacological interventions may be analysed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT02057497
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02057497 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Profil Institut für Stoffwechselforschung GmbH
- Last refreshed: 20 October 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02057497.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing