Comparing the Effects of Digoxin and Ivabradine on Mortality and Morbidity in Chronic Heart Failure With Reduced Ejection Fraction and Sinus Rhythm (DIVA-REF)

NCT02046044 Phase 4 UNKNOWN

Study hypothesis: Comparing the effect of digoxin and ivabradine in chronic heart failure patients with a left ventricular ejection of 35% or lower and sinus rhythm with heart rate 70 beats per minute or higher, and who are taking maximal dose of a beta blocker if tolerated.

Details

Lead sponsor	Kocaeli University
Phase	Phase 4
Status	UNKNOWN
Enrolment	60
Start date	2014-01
Completion	2014-10

Conditions

• Heart Failure

Interventions

• Digoxin
• Ivabradine

Primary outcomes

• Cardiac function and functional status and biochemical parameters — After 6 months
  Cardiac function (echocardiography): Systolic function (left ventricular ejection fraction) and diastolic function (Doppler E/A ratio, tissue Doppler e/e1 ratio, Doppler deceleration time of the E wave, left atrium volume index) Maximal oxygen consumption will be evaluated with cardiopulmonary exercise testing Changes in proBNP level (serum value) after treatment

Countries

Turkey (Türkiye)