NCT02041039

Reward System Responses to Food Aromas

Completed Last updated 11 July 2024

What this trial tests

trial in Adiposity in 332 participants. Completed in 11 September 2015.

Timeline

15 April 2011

Primary endpoint
11 September 2015

11 September 2015

Quick facts

Lead sponsor	Robert Considine
Status	Completed
Study type	OBSERVATIONAL
Enrollment	332
Start date	15 April 2011
Primary completion	11 September 2015
Estimated completion	11 September 2015
Sites	1 location across United States

Conditions studied

• Adiposity — all drugs for Adiposity →

Sponsor

Robert Considine

Who can join

Adults 18 to 40, female only, with Adiposity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Food aromas are a part of foods' flavor, and can promote overeating. Alcohol consumption also stimulates appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain regions that respond to food aromas and alcohol, and how they are modified by the amount of body fat and alcohol exposure, will provide critical information about the neural systems that underlie loss of control of eating. Therefore, the main hypotheses of this study are that: A) Lean and obese subjects have different brain responses to food aromas that enhance desire to eat, and B) Acute alcohol intoxication i) enhances the brain's response to food odors, and ii) affects brain systems that inhibit or terminate eating. To test these hypotheses, we have modified functional magnetic resonance imaging (fMRI) paradigms successfully used to study alcoholic drink aromas in subjects at risk for alcoholism.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women.
   Eiler WJ, Dzemidzic M, Case KR, Armstrong CL, et al · · 2014 · cited 14× · PMID 24695888 · DOI 10.3945/ajcn.113.080788