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NCT02025270
MSCs For Treatment of Azoospermic Patients
Completed
Phase 1, PHASE2
Last updated 1 March 2023
What this trial tests
Phase 1, PHASE2 trial testing Stem Cells in Male Infertility in 100 participants. Completed in 20 December 2022.
Timeline
15 October 2012
Primary endpoint
15 October 2016
15 October 2016
20 December 2022
Quick facts
| Lead sponsor | Al-Azhar University |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 15 October 2012 |
| Primary completion | 15 October 2016 |
| Estimated completion | 20 December 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Stem Cells — full drug profile →
Conditions studied
- Male Infertility — all drugs for Male Infertility →
Sponsor
Al-Azhar University
Who can join
Adults 20 to 50, male only, with Male Infertility. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Application of Stem Cell Therapy for Infertility.
Saha S, Roy P, Corbitt C, Kakar SS. · · 2021 · cited 54× · PMID 34203240 · DOI 10.3390/cells10071613 -
Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review.
Zhankina R, Baghban N, Askarov M, Saipiyeva D, et al · · 2021 · cited 49× · PMID 33823925 · DOI 10.1186/s13287-021-02295-9 -
Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia.
Abdelaal NE, Tanga BM, Abdelgawad M, Allam S, et al · · 2021 · cited 19× · PMID 34359947 · DOI 10.3390/cells10071779 -
Emerging Landscape of Mesenchymal Stem Cell Senescence Mechanisms and Implications on Therapeutic Strategies.
Wang J, Zhang M, Wang H. · · 2024 · cited 13× · PMID 39144566 · DOI 10.1021/acsptsci.4c00284 -
Cell-Based Therapy Approaches in Treatment of Non-obstructive Azoospermia.
Roshandel E, Mehravar M, Nikoonezhad M, Alizadeh AM, et al · · 2023 · cited 6× · PMID 36380137 · DOI 10.1007/s43032-022-01115-6 -
Effects of clinical medications on male fertility and prospects for stem cell therapy.
Mo P, Zhao Z, Ke X, Fan Y, et al · · 2023 · cited 5× · PMID 37791073 · DOI 10.3389/fcell.2023.1258574 -
Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial.
Zhankina R, Zhanbyrbekuly U, Askarov M, Zare A, et al · · 2024 · cited 4× · PMID 39033372 · DOI 10.22074/ijfs.2023.2005045.1480 -
Research progress on the mechanism underlying the application of mesenchymal stem cells in the treatment of male infertility.
Tian X, Zhang J, Tang X, Guo X, et al · · 2025 · PMID 41019344 · DOI 10.3389/fendo.2025.1671247
Verify or expand the search:
- PubMed search for NCT02025270
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Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT02025270 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Al-Azhar University
- Last refreshed: 1 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02025270.
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