NCT02012374

Overcoming Learned Non-Use in Chronic Aphasia

Completed NA Last updated 20 December 2022

What this trial tests

NA trial testing Intensive Language Action Therapy in Stroke-induced Aphasia in 24 participants. Completed in 9 July 2015.

Timeline

26 February 2012

Primary endpoint
17 March 2015

9 July 2015

Quick facts

Lead sponsor	University of Massachusetts, Amherst
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	24
Start date	26 February 2012
Primary completion	17 March 2015
Estimated completion	9 July 2015
Sites	1 location across United States

Drugs / interventions tested

• Intensive Language Action Therapy

Conditions studied

• Stroke-induced Aphasia — all drugs for Stroke-induced Aphasia →

Sponsor

University of Massachusetts, Amherst

Who can join

Adults 21 to 90, any sex, with Stroke-induced Aphasia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech. Both treatments involve massed practice communicating, using intensive language action therapy 3 hours/day, 5 days/week for two weeks, followed by six months of a home practice program. One treatment stresses spoken responses as the preferred expressive modality during intensive therapy. Before and after treatment, and following the home practice program and a period of no practice, the investigators will administer several tests and discourse samples to examine changes associated with the treatments. Participants will also undergo structural and functional MRI testing at these time points. The investigators will also attempt to quantify the degree to which improvements following intensive language therapy and home practice correlate with changes in Quality of Life measures as perceived by both participants with aphasia and their significant others. It is hypothesized that, whereas both treatments will lead to improvements in naming practiced words and communicating, outcomes will be enhanced for the group randomly assigned to the "constraint" condition. Moreover, performance will be enhanced on words practiced during the home practice program, including those that were not practiced during intensive therapy. Improved naming will correlate with modulation of 'signature' language and attentional networks, whose variability will depend on remaining viable brain structures. Initial severity and site/extent of lesion should predict patients' ability to transfer gains in naming to improvements in discourse.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Speech and language therapy for aphasia following stroke.
   Brady MC, Kelly H, Godwin J, Enderby P, et al · · 2016 · cited 380× · PMID 27245310 · DOI 10.1002/14651858.cd000425.pub4