NCT02012244 is a NA clinical trial of fentanyl-based analgesia in Colorectal Surgery, sponsored by Severance Hospital.

Who is sponsoring NCT02012244?

NCT02012244 is sponsored by Severance Hospital.

What drugs are being tested in NCT02012244?

Interventions in NCT02012244: fentanyl-based analgesia, local anesthetic wound infiltration-based anlagesia.

What condition does NCT02012244 study?

NCT02012244 studies Colorectal Surgery.

Is NCT02012244 still recruiting?

NCT02012244 is currently completed. Last updated 10 January 2016.

Last reviewed 2016-01-10 · How we verify

NCT02012244

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer

Completed NA Last updated 10 January 2016

What this trial tests

NA trial testing fentanyl-based analgesia in Colorectal Surgery in 60 participants. Completed in 1 December 2015.

Timeline

1 January 2014

Primary endpoint
1 December 2014

1 December 2015

Quick facts

Lead sponsor	Severance Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	60
Start date	1 January 2014
Primary completion	1 December 2014
Estimated completion	1 December 2015
Sites	1 location across South Korea

Drugs / interventions tested

fentanyl-based analgesia — full drug profile →
local anesthetic wound infiltration-based anlagesia — full drug profile →

Conditions studied

Colorectal Surgery — all drugs for Colorectal Surgery →

Sponsor

Severance Hospital

Who can join

Adults 20 to 80, any sex, with Colorectal Surgery. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

NK cell activity
Time frame: 48 hours
NK cell activity : preoperation, POD 1, POD 2
IL-2
Time frame: 48 hours
IL-2 level : preoperation, POD 1, POD 2

Sponsor's own description

The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer: A Randomized Study.
Kim SY, Kim NK, Baik SH, Min BS, et al · · 2016 · cited 27× · PMID 27175664 · DOI 10.1097/md.0000000000003602
Trial watch: local anesthetics in cancer therapy.
Carnet Le Provost K, Kepp O, Kroemer G, Bezu L. · · 2024 · cited 5× · PMID 38504848 · DOI 10.1080/2162402x.2024.2308940
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Nunez-Rodriguez E, Zhang H, Sah D, Cata JP. · · 2025 · cited 1× · PMID 40772525 · DOI 10.1002/adbi.202500122

Verify or expand the search:

Other recruiting trials for Colorectal Surgery

Currently open trials in the same condition.

NCT07388953 — Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimall · NA · recruiting
NCT07486570 — Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery · NA · recruiting
NCT07208786 — Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery · NA · recruiting
NCT07065994 — The Effect of Virtual Reality Glasses Application on Pain and Anxiety Levels in Colorectal Surgery Patients · NA · active not recruiting
NCT06850688 — Impact of Ambulatory Continuous Monitoring Using Remote Monitoring Medicine Within Patient's Care Pathway Following Colo · NA · recruiting

Other Severance Hospital trials

Trials by the same sponsor.

NCT05439278 — Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma · Phase 3 · recruiting
NCT06380803 — Surgical Skill Labs for Robotic Mastectomy and Educational Program Using a Surgical Guide by Artificial Intelligence · recruiting
NCT04108117 — Surgical and Oncologic Outcomes After Robotic Nipple Sparing Mastectomy and Immediate Reconstruction · completed
NCT04585074 — Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery · active not recruiting
NCT03882697 — Ability of Cardio Q for Prediction of Hypotension · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02012244 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Severance Hospital
Last refreshed: 10 January 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02012244.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing