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Assessment of Whole Blood Cold Stored Platelets (Brrr)
The purpose of this study is to determine the life span and functional characteristics of platelets derived from whole blood that has been stored in a refrigerator for up to 21 days. Currently, platelets are separated from red cells shortly after donation and stored at room temperature for no longer than 5 days. This study is considered experimental because; 1) we will be keeping platelets in the original whole blood donor unit in the refrigerator, and 2) we will be reinfusing a small portion of that donation back into the study-subject-donor and tracking how many of the transfused platelets from that unit circulate in the study-subject-donor in the hours and days after transfusion.
Details
| Lead sponsor | Bloodworks |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 31 |
| Start date | 2013-10 |
| Completion | 2015-03 |
Conditions
- Healthy
Interventions
- Blood Collection and autologous re-infusion
Primary outcomes
- To determine the relationship between each donor's fresh and stored platelet recoveries. — Whole blood units will be held for 4-20 days at 4 degrees C, assigned at consent.
The primary endpoint of this study will be to determine the relationship between each donor's fresh and stored platelet recoveries. The lower 95% confidence limit for the data should be that platelet recoveries at the end of storage should be ≥50% of fresh and survivals should be ≥ 1 day.
Countries
United States