Last reviewed · How we verify
NCT02003976
A Randomized Trial Comparing High Tibial Osteotomy Plus Non-Surgical Treatment and Non-Surgical Treatment Alone
NA trial testing Medial Opening Wedge High Tibial Osteotomy (HTO) in Knee Osteoarthritis in 71 participants. Completed in 26 April 2023.
18 April 2023
Quick facts
| Lead sponsor | Western University, Canada |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 71 |
| Start date | 5 September 2014 |
| Primary completion | 18 April 2023 |
| Estimated completion | 26 April 2023 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Medial Opening Wedge High Tibial Osteotomy (HTO)
- Non-Surgical Treatment Program
Conditions studied
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Sponsor
Western University, Canada
Who can join
Adults 25 to 55, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to compare patients with knee osteoarthritis (OA) receiving optimized non-surgical treatment plus surgical realignment of the tibia, or optimized non-surgical treatment only. We hypothesize that outcomes assessed at 12 and 24 months follow-up will suggest favourable changes in patients undergoing surgical realignment when compared to patients receiving non-surgical treatment only.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Surgical interventions for symptomatic mild to moderate knee osteoarthritis.
Palmer JS, Monk AP, Hopewell S, Bayliss LE, et al · · 2019 · cited 30× · PMID 31322289 · DOI 10.1002/14651858.cd012128.pub2 -
High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.
Birmingham TB, Primeau CA, Moyer RF, Bryant DM, et al · · 2025 · cited 5× · PMID 40720836 · DOI 10.7326/annals-25-00920
Verify or expand the search:
- PubMed search for NCT02003976
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Western University, Canada trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02003976 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Western University, Canada
- Last refreshed: 24 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02003976.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing