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NCT02003196: IBIS-VIRUS
Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)
trial in Brain Injury in 375 participants. Completed in 26 March 2020.
26 March 2020
Quick facts
| Lead sponsor | Nantes University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 375 |
| Start date | 5 January 2014 |
| Primary completion | 26 March 2020 |
| Estimated completion | 26 March 2020 |
| Sites | 1 location across France |
Conditions studied
- Brain Injury — all drugs for Brain Injury →
Sponsor
Nantes University Hospital
Who can join
Adults 18 to 75, any sex, with Brain Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Morbidity and mortality of ICU patients is increased by the development of a "immunosuppression" systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral reactivations (Cytomegalovirus or Herpes Simplex Virus). Viral reactivation was associated with increased morbidity and mortality in intensive care units. In clinical practice, they are searched at the onset of organ failure or unexplained fever. The investigators wish to conduct this research in the stroke patients to assess the predictive power of these viral reactivations on the duration of mechanical ventilation.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients.
Anani H, Destras G, Bulteau S, Castain L, et al · · 2025 · cited 2× · PMID 40914165 · DOI 10.1016/j.xcrm.2025.102289 -
Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients.
Petrier M, Sinha D, Martin FP, Poulain C, et al · · 2026 · PMID 41820963 · DOI 10.1186/s13054-026-05946-6 -
Metagenome-assembled complete genome of <i>Bohxovirus</i>, a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients.
Anani H, Destras G, Regue H, Bulteau S, et al · · 2025 · PMID 41159973 · DOI 10.1128/mra.00592-25
Verify or expand the search:
- PubMed search for NCT02003196
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Nantes University Hospital trials
Trials by the same sponsor.
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- NCT07467382 — GOAT (Gait Observation of Achilles Tendon) · not yet recruiting
- NCT07490379 — Comparison of the Efficacy of Transcranial Direct Current Stimulation at Home Versus in Hospital Settings in Patients Wi · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02003196 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nantes University Hospital
- Last refreshed: 25 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02003196.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing