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NCT01980550
Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Phase 4 trial testing sublingual nicotine in Nicotine Dependence in 250 participants. Completed in 1 December 2004.
1 December 2004
Quick facts
| Lead sponsor | National Institute on Drug Dependence, China |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | double |
| Enrollment | 250 |
| Start date | 1 March 2004 |
| Primary completion | 1 December 2004 |
| Estimated completion | 1 December 2004 |
Drugs / interventions tested
- sublingual nicotine — full drug profile →
Conditions studied
- Nicotine Dependence — all drugs for Nicotine Dependence →
Sponsor
National Institute on Drug Dependence, China
Who can join
Adults 20 to 70, any sex, with Nicotine Dependence. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Changes in the exhaled carbon monoxide (CO) level during the 12-week study
Time frame: The first was 1 day before quit day (baseline), followed by visits after 1, 2, 4, 6 and 8 weeks at the end of treatment (EOT), with a final follow-up visit at 12 weeks.
Sponsor's own description
Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. The investigators evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial among Chinese smokers.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT01980550
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Nicotine Dependence
Currently open trials in the same condition.
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- NCT07250230 — Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Un · NA · recruiting
- NCT07040566 — A Trial of Varenicline for E-cigarette Cessation · Phase 2 · recruiting
- NCT07001930 — Effects of Cannabidiol on Stress and Nicotine Withdrawal · Phase 1 · recruiting
- NCT06765291 — Behavioral Intervention for Youth to Promote Vaping Cessation · NA · recruiting
Other National Institute on Drug Dependence, China trials
Trials by the same sponsor.
- NCT04622748 — Neurocognitive Functions of Recovered COVID-19 Patients · unknown
- NCT04349748 — MHealth Intervention of HIV and STDs Partner Notification for MSM · NA · unknown
- NCT04133974 — Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01980550 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute on Drug Dependence, China
- Last refreshed: 10 November 2013
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01980550.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing