NCT01980511: NeuroVISION

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Completed Last updated 10 January 2019

What this trial tests

trial in Covert Postoperative Stroke in 1,116 participants. Completed in 6 November 2018.

Timeline

24 March 2014

Primary endpoint
11 October 2018

6 November 2018

Quick facts

Lead sponsor	McMaster University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,116
Start date	24 March 2014
Primary completion	11 October 2018
Estimated completion	6 November 2018
Sites	11 locations across Hong Kong, New Zealand, Malaysia, Peru, Chile, Poland, Canada, United States

Conditions studied

• Covert Postoperative Stroke — all drugs for Covert Postoperative Stroke →

Sponsor

McMaster University

Who can join

65 and older, any sex, with Covert Postoperative Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The NeuroVISION Study will characterize the incidence, impact, and risk factors of covert stroke in adults undergoing noncardiac surgery. We will determine the incidence of acute covert stroke using an MRI study of the brain in the days following noncardiac surgery. We will characterize the epidemiology and the impact of covert stroke in patients undergoing noncardiac surgery, and its association with cerebral deoxygenation.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study.
   Taylor J, Parker M, Casey CP, Tanabe S, et al · · 2022 · cited 160× · PMID 35144802 · DOI 10.1016/j.bja.2022.01.005
2. Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function.
   Taylor J, Wu JG, Kunkel D, Parker M, et al · · 2023 · cited 29× · PMID 37385855 · DOI 10.1016/j.bja.2023.05.023
3. Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements.
   Lindroth H, Nair VA, Stanfield C, Casey C, et al · · 2019 · cited 24× · PMID 31375692 · DOI 10.1038/s41598-019-47294-2
4. Predicting postoperative delirium severity in older adults: The role of surgical risk and executive function.
   Lindroth H, Bratzke L, Twadell S, Rowley P, et al · · 2019 · cited 23× · PMID 30907449 · DOI 10.1002/gps.5104
5. Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies.
   Taylor J, Eisenmenger L, Lindroth H, Booth J, et al · · 2023 · cited 13× · PMID 36437124 · DOI 10.1016/j.bja.2022.10.018
6. Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study.
   Payne T, Taylor J, Casey C, Kunkel D, et al · · 2023 · cited 12× · PMID 36842841 · DOI 10.1016/j.bja.2023.01.020
7. Sevoflurane dose and postoperative delirium: a prospective cohort analysis.
   Taylor J, Payne T, Casey C, Kunkel D, et al · · 2023 · cited 12× · PMID 36192219 · DOI 10.1016/j.bja.2022.08.022
8. Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study.
   Mrkobrada M, Chan MTV, Cowan D, Spence J, et al · · 2018 · cited 11× · PMID 29982215 · DOI 10.1136/bmjopen-2018-021521