In Vivo and In Vitro Efficacy of Artemisinin Combination Therapy in Kisumu County, Western Kenya

NCT01976780 Phase 4 COMPLETED

This study aims to assess the degree of artemisinin resistance in adult and pediatric subjects presenting with uncomplicated falciparum malaria in Western Kenya. The study treatments will be Artemether Lumefantrine (AL) and Artesunate Mefloquine (ASMQ).

Details

Lead sponsor	Global Emerging Infections Surveillance and Response System
Phase	Phase 4
Status	COMPLETED
Enrolment	118
Start date	2013-06
Completion	2014-12

Conditions

• Malaria

Interventions

• Artesunate
• Artemether Lumefantrine
• Mefloquine

Primary outcomes

• Parasitological clearance rates by microscopy — 72 hours
  Clearance rates for the first 72 hour period after first ACT dose in patients with uncomplicated P. falciparum malaria

Countries

Kenya