Effects of High and Low Dose Vitamin D Suppletion on Postprandial Leukocyte Activation, Oxidative Stress and Vascular Function in Healthy Overweight and Obese Females (DOSFEM)

NCT01967459 NA COMPLETED

Administration of vitamin D will have a beneficial effect on postprandial leukocyte activation, oxidative stress and arterial stiffness in vitamin D deficient females. High doses of vitamin D may have a more pronounced effect than low doses.

Details

Lead sponsor	Sint Franciscus Gasthuis
Phase	NA
Status	COMPLETED
Enrolment	24
Start date	2013-10
Completion	2015-12

Conditions

• Atherosclerosis
• Oxidative Stress
• Leukocyte Activation Disorder

Interventions

• Cholecalciferol
• Cholecalciferol

Primary outcomes

• effect of vitamin D on leukocyte cluster of differentiation antigen 11b expression — 2, 4, 6 and 8 hours postprandial
  the differential effect of 75 000 IU low dose vs. 300 000 IU high dose vitamin D on postprandial leukocyte activation markers cluster of differentiation antigen 11b

Countries

Netherlands