Who is sponsoring NCT01952782?

NCT01952782 is sponsored by Massachusetts General Hospital.

What drugs are being tested in NCT01952782?

Interventions in NCT01952782: Kisspeptin 112-121, Naloxone, GnRH.

What condition does NCT01952782 study?

NCT01952782 studies Hypogonadotropic Hypogonadism.

Is NCT01952782 still recruiting?

NCT01952782 is currently completed. Last updated 31 July 2024.

Last reviewed 2024-07-31 · How we verify

NCT01952782

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neuropeptides in Human Reproduction

Completed Phase 1 Last updated 31 July 2024

What this trial tests

Phase 1 trial testing Kisspeptin 112-121 in Hypogonadotropic Hypogonadism in 61 participants. Completed in 31 May 2016.

Timeline

30 April 2014

Primary endpoint
31 May 2016

31 May 2016

Quick facts

Lead sponsor	Massachusetts General Hospital
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	61
Start date	30 April 2014
Primary completion	31 May 2016
Estimated completion	31 May 2016
Sites	1 location across United States

Drugs / interventions tested

Kisspeptin 112-121 — full drug profile →
Naloxone (NALOXONE) — full drug profile →
GnRH — full drug profile →

Conditions studied

Hypogonadotropic Hypogonadism — all drugs for Hypogonadotropic Hypogonadism →

Sponsor

Massachusetts General Hospital

Who can join

Adults 18 to 75, any sex, with Hypogonadotropic Hypogonadism. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of gonadotropin-releasing hormone (GnRH) and kisspeptin, two other naturally occurring reproductive hormones.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling.
Lippincott MF, León S, Chan YM, Fergani C, et al · · 2019 · cited 25× · PMID 31132118 · DOI 10.1210/jc.2019-00146
Divergent responses to kisspeptin in children with delayed puberty.
Chan YM, Lippincott MF, Kusa TO, Seminara SB. · · 2018 · cited 15× · PMID 29669934 · DOI 10.1172/jci.insight.99109
Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.
Sliwowska JH, Woods NE, Alzahrani AR, Paspali E, et al · · 2024 · cited 9× · PMID 38599822 · DOI 10.1111/1753-0407.13541
Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.
Chen X, Yang S, Shaw ND, Xia M. · · 2025 · cited 1× · PMID 40430029 · DOI 10.3390/ijms26104890

Verify or expand the search:

Other trials of Kisspeptin 112-121

Trials testing the same drug.

NCT05633966 — Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders · Phase 1 · completed
NCT02956447 — Administration of Kisspeptin in Patients With Hyperprolactinemia · Phase 2 · completed

Other recruiting trials for Hypogonadotropic Hypogonadism

Currently open trials in the same condition.

NCT06357442 — Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Dail · recruiting

Other Massachusetts General Hospital trials

Trials by the same sponsor.

NCT03585946 — Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis · withdrawn
NCT07214831 — A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerg · NA · not yet recruiting
NCT06686901 — A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior · NA · not yet recruiting
NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01952782 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
Last refreshed: 31 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01952782.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing