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NCT01948622
Anxiety Control by Using Erythrina Mulungu in Mandibular Third Molars Extraction
Phase 1/Phase 2 trial testing Mulungu in Dental Anxiety in 30 participants. Completed in 1 November 2012.
1 June 2012
Quick facts
| Lead sponsor | Liane Maciel de Almeida Souza |
|---|---|
| Phase | Phase 1/Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 January 2012 |
| Primary completion | 1 June 2012 |
| Estimated completion | 1 November 2012 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Mulungu — full drug profile →
- Placebo
Conditions studied
- Dental Anxiety — all drugs for Dental Anxiety →
- Impacted Third Molar Tooth — all drugs for Impacted Third Molar Tooth →
Sponsor
Liane Maciel de Almeida Souza — full company profile →
Who can join
Adults 18 to 35, any sex, with Dental Anxiety or Impacted Third Molar Tooth. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Changes in anxiety report
Time frame: Change from baseline to 7 days
Changes in the subjects' anxiety level was observed by using a Modified Corah Dental Anxiety Scale in three times: at baseline, in the day of surgery and after 7 days of the procedure.
Sponsor's own description
This study evaluated the effectiveness of the Erythrina mulungu in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
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Effect of Erythrinamu lungu on anxiety during extraction of third molars.
Silveira-Souto ML, São-Mateus CR, de Almeida-Souza LM, Groppo FC. · · 2014 · cited 6× · PMID 24880443 · DOI 10.4317/medoral.19511 -
Pharmacology activity, toxicity, and clinical trials of Erythrina genus plants (Fabaceae): an evidence-based review.
Susilawati E, Levita J, Susilawati Y, Sumiwi SA. · · 2023 · cited 4× · PMID 38044940 · DOI 10.3389/fphar.2023.1281150
Verify or expand the search:
- PubMed search for NCT01948622
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Dental Anxiety
Currently open trials in the same condition.
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- NCT07398898 — Use of Augmented Reality Glasses and Noise-Cancelling Headphones to Reduce Dental Anxiety in Adult Patients · NA · recruiting
- NCT07209696 — Storybook and Animation Video Adjuncts to Tell-Show-Do in Pediatric Dentistry · NA · active not recruiting
- NCT07274501 — The Effect of Music That the Individuals With Moderate Dental Anxiety Have Started Listening to While Waiting · NA · active not recruiting
- NCT07173491 — Music Therapy in Restorative Dentistry · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01948622 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Liane Maciel de Almeida Souza
- Last refreshed: 18 September 2013
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01948622.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing