NCT01942109 (TORNADO) is a Phase 4 clinical trial of Furosemide in Heart Failure, sponsored by Medical University of Warsaw.

Who is sponsoring NCT01942109?

NCT01942109 is sponsored by Medical University of Warsaw.

What drugs are being tested in NCT01942109?

Interventions in NCT01942109: Furosemide, Torasemide.

What condition does NCT01942109 study?

NCT01942109 studies Heart Failure.

Is NCT01942109 still recruiting?

NCT01942109 is currently status unknown. Last updated 7 June 2017.

Last reviewed 2017-06-07 · How we verify

NCT01942109: TORNADO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure - Prospective, Randomized, Open, Blinded Endpoint Trial

Status unknown Phase 4 Last updated 7 June 2017

What this trial tests

Phase 4 trial testing Furosemide in Heart Failure in 100 participants. Status unknown.

Timeline

1 September 2013

Primary endpoint
1 December 2017

1 December 2018

Quick facts

Lead sponsor	Medical University of Warsaw
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	100
Start date	1 September 2013
Primary completion	1 December 2017
Estimated completion	1 December 2018
Sites	2 locations across Poland

Drugs / interventions tested

Furosemide (furosemide) — full drug profile →
Torasemide — full drug profile →

Conditions studied

Heart Failure — all drugs for Heart Failure →

Sponsor

Medical University of Warsaw

Who can join

18 and older, any sex, with Heart Failure. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

The influence of therapy on cardiovascular events associated with heart failure (deaths, hospitalisations)
Time frame: up to 12 months

Sponsor's own description

The aim of the study is to compare the effects of torasemide and furosemide on clinical and biochemical parameters of hemodynamic and neurohormonal compensation and myocardial remodeling in patients with chronic heart failure with indications for use of loop diuretics. The study protocol 100 patients with heart failure NYHA (New York Heart Association) II-IV (stable or exacerbation aligned cardiopulmonary at the time of enrollment, with a fixed-dose loop diuretics\]) treated with optimal medical therapy as clinically indicated for use loop diuretics. Patients will be randomized to treatment with furosemide and torasemide (randomization 1 : 1). After randomization, furosemide will continue in its current fixed-dose or will be replaced by equipotential dose of torasemide (4:1). The minimal follow-up of patients in the study will be at least six months.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Comparative effectiveness of torasemide versus furosemide in symptomatic therapy in heart failure patients: Preliminary results from the randomized TORNADO trial.
Balsam P, Ozierański K, Marchel M, Gawałko M, et al · · 2019 · cited 15× · PMID 31909470 · DOI 10.5603/cj.a2019.0114
Multimodal Strategies for the Diagnosis and Management of Refractory Congestion. An Integrated Cardiorenal Approach.
Rodríguez-Espinosa D, Guzman-Bofarull J, De La Fuente-Mancera JC, Maduell F, et al · · 2022 · cited 8× · PMID 35874534 · DOI 10.3389/fphys.2022.913580
The impact of torasemide on haemodynamic and neurohormonal stress, and cardiac remodelling in heart failure - TORNADO: a study protocol for a randomized controlled trial.
Balsam P, Ozierański K, Tymińska A, Główczyńska R, et al · · 2017 · cited 1× · PMID 28114980 · DOI 10.1186/s13063-016-1760-z

Verify or expand the search:

Other trials of Furosemide

Trials testing the same drug.

NCT07431866 — A Clinical Study of the Effect of MK-2828 on Rosuvastatin or Furosemide in Healthy People (MK-2828-005) · Phase 1 · recruiting
NCT06941415 — Bumetanide vs. Furosemide in Cirrhosis · Phase 3 · not yet recruiting
NCT07348510 — Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures · NA · recruiting
NCT06821594 — Role of Intralesional Combined Injection of Furosemide and Digoxin in Cutaneous Warts at Tertiary Care Hospital in Karac · EARLY_PHASE1 · enrolling by invitation
NCT06899061 — Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saru · Phase 1 · active not recruiting

Other recruiting trials for Heart Failure

Currently open trials in the same condition.

NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting

Other Medical University of Warsaw trials

Trials by the same sponsor.

NCT07515768 — TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol · NA · not yet recruiting
NCT07511907 — Routine Intraoperative White Test for Bile Leak Detection in Liver Resection · NA · not yet recruiting
NCT07498660 — PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomize · NA · not yet recruiting
NCT07398898 — Use of Augmented Reality Glasses and Noise-Cancelling Headphones to Reduce Dental Anxiety in Adult Patients · NA · recruiting
NCT07237204 — 15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01942109 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Warsaw
Last refreshed: 7 June 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01942109.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing